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Permeability of a Cell Membrane Junction : Dependence on energy metabolism

The ion permeability of the membrane junctions between Chironomus salivary gland cells is strongly depressed by treatments that are generally known to inhibit energy metabolism. These treatments include prolonged cooling at 6°–8°C, and exposure to dinitrophenol, cyanide, oligomycin, and N-ethylmalei...

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Detalles Bibliográficos
Autores principales: Politoff, A. L., Socolar, S. J., Loewenstein, W. R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2202868/
https://www.ncbi.nlm.nih.gov/pubmed/5778320
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author Politoff, A. L.
Socolar, S. J.
Loewenstein, W. R.
author_facet Politoff, A. L.
Socolar, S. J.
Loewenstein, W. R.
author_sort Politoff, A. L.
collection PubMed
description The ion permeability of the membrane junctions between Chironomus salivary gland cells is strongly depressed by treatments that are generally known to inhibit energy metabolism. These treatments include prolonged cooling at 6°–8°C, and exposure to dinitrophenol, cyanide, oligomycin, and N-ethylmaleimide. Intracellular injection of ATP appears to prevent depression of junctional permeability by dinitrophenol or to reverse it. Ouabain, azide, p-chloromercuriphenylsulfonic acid, reserpine, and acetazolamide fail to depress junctional permeability. Thus the ion permeability of the junctional membranes appears to depend on energy provided by oxidative phosphorylation. Possible energy-linked processes for maintaining junctional permeability are discussed, including processes involving transport of permeability-modifying species such as Ca(++).
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spelling pubmed-22028682008-04-23 Permeability of a Cell Membrane Junction : Dependence on energy metabolism Politoff, A. L. Socolar, S. J. Loewenstein, W. R. J Gen Physiol Article The ion permeability of the membrane junctions between Chironomus salivary gland cells is strongly depressed by treatments that are generally known to inhibit energy metabolism. These treatments include prolonged cooling at 6°–8°C, and exposure to dinitrophenol, cyanide, oligomycin, and N-ethylmaleimide. Intracellular injection of ATP appears to prevent depression of junctional permeability by dinitrophenol or to reverse it. Ouabain, azide, p-chloromercuriphenylsulfonic acid, reserpine, and acetazolamide fail to depress junctional permeability. Thus the ion permeability of the junctional membranes appears to depend on energy provided by oxidative phosphorylation. Possible energy-linked processes for maintaining junctional permeability are discussed, including processes involving transport of permeability-modifying species such as Ca(++). The Rockefeller University Press 1969-04-01 /pmc/articles/PMC2202868/ /pubmed/5778320 Text en Copyright © 1969 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Politoff, A. L.
Socolar, S. J.
Loewenstein, W. R.
Permeability of a Cell Membrane Junction : Dependence on energy metabolism
title Permeability of a Cell Membrane Junction : Dependence on energy metabolism
title_full Permeability of a Cell Membrane Junction : Dependence on energy metabolism
title_fullStr Permeability of a Cell Membrane Junction : Dependence on energy metabolism
title_full_unstemmed Permeability of a Cell Membrane Junction : Dependence on energy metabolism
title_short Permeability of a Cell Membrane Junction : Dependence on energy metabolism
title_sort permeability of a cell membrane junction : dependence on energy metabolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2202868/
https://www.ncbi.nlm.nih.gov/pubmed/5778320
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