Accumulation of Iron in the Rabbit Erythroid Cell As Affected by Ouabain, Sodium and Potassium Ions, and Temperature

Reticulocytosis was induced in rabbits with phenylhydrazine. The accumulation of a small part of (59)Fe in blood cells of these animals was inhibited by ouabain and related to changes in extracellular sodium and potassium concentrations. Sodium increases movement from the cell surface into the cell,...

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Detalles Bibliográficos
Autores principales: Wise, W. C., Archdeacon, J. W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2202869/
https://www.ncbi.nlm.nih.gov/pubmed/4238083
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author Wise, W. C.
Archdeacon, J. W.
author_facet Wise, W. C.
Archdeacon, J. W.
author_sort Wise, W. C.
collection PubMed
description Reticulocytosis was induced in rabbits with phenylhydrazine. The accumulation of a small part of (59)Fe in blood cells of these animals was inhibited by ouabain and related to changes in extracellular sodium and potassium concentrations. Sodium increases movement from the cell surface into the cell, whereas potassium and ouabain decrease this movement. (59)Fe movement was found to be temperature-dependent. Thus, the Na-K ATPase system appears to be important in the movement of iron from the cell membrane (stroma) to the cell interior, but influences only a small part of the total iron transport.
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spelling pubmed-22028692008-04-23 Accumulation of Iron in the Rabbit Erythroid Cell As Affected by Ouabain, Sodium and Potassium Ions, and Temperature Wise, W. C. Archdeacon, J. W. J Gen Physiol Article Reticulocytosis was induced in rabbits with phenylhydrazine. The accumulation of a small part of (59)Fe in blood cells of these animals was inhibited by ouabain and related to changes in extracellular sodium and potassium concentrations. Sodium increases movement from the cell surface into the cell, whereas potassium and ouabain decrease this movement. (59)Fe movement was found to be temperature-dependent. Thus, the Na-K ATPase system appears to be important in the movement of iron from the cell membrane (stroma) to the cell interior, but influences only a small part of the total iron transport. The Rockefeller University Press 1969-04-01 /pmc/articles/PMC2202869/ /pubmed/4238083 Text en Copyright © 1969 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Wise, W. C.
Archdeacon, J. W.
Accumulation of Iron in the Rabbit Erythroid Cell As Affected by Ouabain, Sodium and Potassium Ions, and Temperature
title Accumulation of Iron in the Rabbit Erythroid Cell As Affected by Ouabain, Sodium and Potassium Ions, and Temperature
title_full Accumulation of Iron in the Rabbit Erythroid Cell As Affected by Ouabain, Sodium and Potassium Ions, and Temperature
title_fullStr Accumulation of Iron in the Rabbit Erythroid Cell As Affected by Ouabain, Sodium and Potassium Ions, and Temperature
title_full_unstemmed Accumulation of Iron in the Rabbit Erythroid Cell As Affected by Ouabain, Sodium and Potassium Ions, and Temperature
title_short Accumulation of Iron in the Rabbit Erythroid Cell As Affected by Ouabain, Sodium and Potassium Ions, and Temperature
title_sort accumulation of iron in the rabbit erythroid cell as affected by ouabain, sodium and potassium ions, and temperature
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2202869/
https://www.ncbi.nlm.nih.gov/pubmed/4238083
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