Regulatory Mechanisms of the Calcium Transport System of Fragmented Rabbit Sarcoplasmic Reticulum : II. Inhibition of outflux in calcium-free media

The outflux of calcium from vesicles of sarcoplasmic reticulum is controlled by the concentration of ionized calcium in the medium. In a calcium-free medium calcium outflux is at a minimum provided ATP and Mg are present. If they are removed calcium outflux becomes rapid and has a rate constant simi...

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Detalles Bibliográficos
Autor principal: Weber, A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1971
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203095/
https://www.ncbi.nlm.nih.gov/pubmed/5539339
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author Weber, A.
author_facet Weber, A.
author_sort Weber, A.
collection PubMed
description The outflux of calcium from vesicles of sarcoplasmic reticulum is controlled by the concentration of ionized calcium in the medium. In a calcium-free medium calcium outflux is at a minimum provided ATP and Mg are present. If they are removed calcium outflux becomes rapid and has a rate constant similar to that of outflux during steady-state (40)Ca-(45)Ca exchange with saturating calcium concentrations in the medium. In order to maintain the low permeability state of the membrane only the presence but not the continued hydrolysis of ATP is necessary.
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spelling pubmed-22030952008-04-23 Regulatory Mechanisms of the Calcium Transport System of Fragmented Rabbit Sarcoplasmic Reticulum : II. Inhibition of outflux in calcium-free media Weber, A. J Gen Physiol Article The outflux of calcium from vesicles of sarcoplasmic reticulum is controlled by the concentration of ionized calcium in the medium. In a calcium-free medium calcium outflux is at a minimum provided ATP and Mg are present. If they are removed calcium outflux becomes rapid and has a rate constant similar to that of outflux during steady-state (40)Ca-(45)Ca exchange with saturating calcium concentrations in the medium. In order to maintain the low permeability state of the membrane only the presence but not the continued hydrolysis of ATP is necessary. The Rockefeller University Press 1971-01-01 /pmc/articles/PMC2203095/ /pubmed/5539339 Text en Copyright © 1971 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Weber, A.
Regulatory Mechanisms of the Calcium Transport System of Fragmented Rabbit Sarcoplasmic Reticulum : II. Inhibition of outflux in calcium-free media
title Regulatory Mechanisms of the Calcium Transport System of Fragmented Rabbit Sarcoplasmic Reticulum : II. Inhibition of outflux in calcium-free media
title_full Regulatory Mechanisms of the Calcium Transport System of Fragmented Rabbit Sarcoplasmic Reticulum : II. Inhibition of outflux in calcium-free media
title_fullStr Regulatory Mechanisms of the Calcium Transport System of Fragmented Rabbit Sarcoplasmic Reticulum : II. Inhibition of outflux in calcium-free media
title_full_unstemmed Regulatory Mechanisms of the Calcium Transport System of Fragmented Rabbit Sarcoplasmic Reticulum : II. Inhibition of outflux in calcium-free media
title_short Regulatory Mechanisms of the Calcium Transport System of Fragmented Rabbit Sarcoplasmic Reticulum : II. Inhibition of outflux in calcium-free media
title_sort regulatory mechanisms of the calcium transport system of fragmented rabbit sarcoplasmic reticulum : ii. inhibition of outflux in calcium-free media
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203095/
https://www.ncbi.nlm.nih.gov/pubmed/5539339
work_keys_str_mv AT webera regulatorymechanismsofthecalciumtransportsystemoffragmentedrabbitsarcoplasmicreticulumiiinhibitionofoutfluxincalciumfreemedia

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