Characteristics of Chloride Transport in Human Red Blood Cells

The efflux of chloride-36 from human erythrocytes under steady-state conditions is a saturable process that is competitively inhibited by bicarbonate and noncompetitively inhibited by acetate. This chloride self-exchange flux is reversibly dependent on the pH of the medium between 5.7 and 9.6 with a...

Descripción completa

Detalles Bibliográficos
Autores principales: Gunn, Robert B., Dalmark, Mads, Tosteson, D. C., Wieth, J. O.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1973
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203467/
https://www.ncbi.nlm.nih.gov/pubmed/4688320
_version_ 1782148386239021056
author Gunn, Robert B.
Dalmark, Mads
Tosteson, D. C.
Wieth, J. O.
author_facet Gunn, Robert B.
Dalmark, Mads
Tosteson, D. C.
Wieth, J. O.
author_sort Gunn, Robert B.
collection PubMed
description The efflux of chloride-36 from human erythrocytes under steady-state conditions is a saturable process that is competitively inhibited by bicarbonate and noncompetitively inhibited by acetate. This chloride self-exchange flux is reversibly dependent on the pH of the medium between 5.7 and 9.6 with a maximum flux at pH 7.8. The increase in chloride flux between pH 5.7 and 7.8 is inexplicable by the fixed charge hypothesis. The interpretations are made that chloride transport in human erythrocytes is carrier mediated, that bicarbonate utilizes the same transport mechanism, and that the mechanism can be titrated with hydrogen ions into less functional forms for chloride transport.
format Text
id pubmed-2203467
institution National Center for Biotechnology Information
language English
publishDate 1973
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-22034672008-04-23 Characteristics of Chloride Transport in Human Red Blood Cells Gunn, Robert B. Dalmark, Mads Tosteson, D. C. Wieth, J. O. J Gen Physiol Article The efflux of chloride-36 from human erythrocytes under steady-state conditions is a saturable process that is competitively inhibited by bicarbonate and noncompetitively inhibited by acetate. This chloride self-exchange flux is reversibly dependent on the pH of the medium between 5.7 and 9.6 with a maximum flux at pH 7.8. The increase in chloride flux between pH 5.7 and 7.8 is inexplicable by the fixed charge hypothesis. The interpretations are made that chloride transport in human erythrocytes is carrier mediated, that bicarbonate utilizes the same transport mechanism, and that the mechanism can be titrated with hydrogen ions into less functional forms for chloride transport. The Rockefeller University Press 1973-02-01 /pmc/articles/PMC2203467/ /pubmed/4688320 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Gunn, Robert B.
Dalmark, Mads
Tosteson, D. C.
Wieth, J. O.
Characteristics of Chloride Transport in Human Red Blood Cells
title Characteristics of Chloride Transport in Human Red Blood Cells
title_full Characteristics of Chloride Transport in Human Red Blood Cells
title_fullStr Characteristics of Chloride Transport in Human Red Blood Cells
title_full_unstemmed Characteristics of Chloride Transport in Human Red Blood Cells
title_short Characteristics of Chloride Transport in Human Red Blood Cells
title_sort characteristics of chloride transport in human red blood cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2203467/
https://www.ncbi.nlm.nih.gov/pubmed/4688320
work_keys_str_mv AT gunnrobertb characteristicsofchloridetransportinhumanredbloodcells
AT dalmarkmads characteristicsofchloridetransportinhumanredbloodcells
AT tostesondc characteristicsofchloridetransportinhumanredbloodcells
AT wiethjo characteristicsofchloridetransportinhumanredbloodcells

Ejemplares similares