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Optimal design and validation of antiviral siRNA for targeting HIV-1

We propose rational designing of antiviral short-interfering RNA (siRNA) targeting highly divergent HIV-1. In this study, conserved regions within HIV-1 genomes were identified through an exhaustive computational analysis, and the functionality of siRNAs targeting the highest possible conserved regi...

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Detalles Bibliográficos
Autores principales:	Naito, Yuki, Nohtomi, Kyoko, Onogi, Toshinari, Uenishi, Rie, Ui-Tei, Kumiko, Saigo, Kaoru, Takebe, Yutaka
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2204037/ https://www.ncbi.nlm.nih.gov/pubmed/17996047 http://dx.doi.org/10.1186/1742-4690-4-80

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