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Endothelin potentiates TRPV1 via ET(A )receptor-mediated activation of protein kinase C

BACKGROUND: Endothelin-1 (ET-1) both stimulates nociceptors and sensitizes them to noxious stimuli, an effect probably mediated by the ET(A )receptor (ET(A)R) expressed in sensory neurons. The cellular mechanisms of this ET-1-mediated effect are only poorly understood. TRPV1, the heat-, pH- and caps...

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Detalles Bibliográficos
Autores principales:	Plant, Tim D, Zöllner, Christian, Kepura, Frauke, Mousa, Shaaban S, Eichhorst, Jenny, Schaefer, Michael, Furkert, Jens, Stein, Christoph, Oksche, Alexander
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206006/ https://www.ncbi.nlm.nih.gov/pubmed/18001466 http://dx.doi.org/10.1186/1744-8069-3-35

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