Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition

c-myc is essential for cell homeostasis and growth but lethal if improperly regulated. Transcription of this oncogene is governed by the counterbalancing forces of two proteins on TFIIH—the FUSE binding protein (FBP) and the FBP-interacting repressor (FIR). FBP and FIR recognize single-stranded DNA...

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Detalles Bibliográficos
Autores principales: Crichlow, Gregg V, Zhou, Hongwen, Hsiao, Hsin-hao, Frederick, Kendra B, Debrosse, Maxime, Yang, Yuande, Folta-Stogniew, Ewa J, Chung, Hye-Jung, Fan, Chengpeng, De La Cruz, Enrique M, Levens, David, Lolis, Elias, Braddock, Demetrios
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206118/
https://www.ncbi.nlm.nih.gov/pubmed/18059478
http://dx.doi.org/10.1038/sj.emboj.7601936

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