Lipids revert inert Aβ amyloid fibrils to neurotoxic protofibrils that affect learning in mice

Although soluble oligomeric and protofibrillar assemblies of Aβ-amyloid peptide cause synaptotoxicity and potentially contribute to Alzheimer's disease (AD), the role of mature Aβ-fibrils in the amyloid plaques remains controversial. A widely held view in the field suggests that the fibrillizat...

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Detalles Bibliográficos
Autores principales: Martins, Ivo Cristiano, Kuperstein, Inna, Wilkinson, Hannah, Maes, Elke, Vanbrabant, Mieke, Jonckheere, Wim, Van Gelder, Patrick, Hartmann, Dieter, D'Hooge, Rudi, De Strooper, Bart, Schymkowitz, Joost, Rousseau, Frederic
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206134/
https://www.ncbi.nlm.nih.gov/pubmed/18059472
http://dx.doi.org/10.1038/sj.emboj.7601953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206134/
https://www.ncbi.nlm.nih.gov/pubmed/18059472
http://dx.doi.org/10.1038/sj.emboj.7601953

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