Cargando…

Constitutive upregulation of the transforming growth factor-β pathway in rheumatoid arthritis synovial fibroblasts

Genome-wide gene expression was comparatively investigated in early-passage rheumatoid arthritis (RA) and osteoarthritis (OA) synovial fibroblasts (SFBs; n = 6 each) using oligonucleotide microarrays; mRNA/protein data were validated by quantitative PCR (qPCR) and western blotting and immunohistoche...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pohlers, Dirk, Beyer, Andreas, Koczan, Dirk, Wilhelm, Thomas, Thiesen, Hans-Jürgen, Kinne, Raimund W
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206335/ https://www.ncbi.nlm.nih.gov/pubmed/17594488 http://dx.doi.org/10.1186/ar2217

Ejemplares similares

Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane
por: Huber, René, et al.
Publicado: (2008)

Novel application of multi-stimuli network inference to synovial fibroblasts of rheumatoid arthritis patients
por: Kupfer, Peter, et al.
Publicado: (2014)

Robust computational reconstitution – a new method for the comparative analysis of gene expression in tissues and isolated cell fractions
por: Hoffmann, Martin, et al.
Publicado: (2006)

Batch correction of microarray data substantially improves the identification of genes differentially expressed in Rheumatoid Arthritis and Osteoarthritis
por: Kupfer, Peter, et al.
Publicado: (2012)

In vitro model for the analysis of synovial fibroblast-mediated degradation of intact cartilage
por: Pretzel, David, et al.
Publicado: (2009)

Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation
por: Woetzel, Dirk, et al.
Publicado: (2014)

Cytoskeletal Rearrangements in Synovial Fibroblasts as a Novel Pathophysiological Determinant of Modeled Rheumatoid Arthritis
por: Aidinis, Vassilis, et al.
Publicado: (2005)

Correction: Cytoskeletal Rearrangements in Synovial Fibroblasts as a Novel Pathophysiological Determinant of Modeled Rheumatoid Arthritis
por: Aidinis, Vassilis, et al.
Publicado: (2005)

High CXCR3 expression in synovial mast cells associated with CXCL9 and CXCL10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis
por: Ruschpler, Peter, et al.
Publicado: (2003)

Functional analysis of an arthritogenic synovial fibroblast
por: Aidinis, Vassilis, et al.
Publicado: (2003)

Adapted Boolean network models for extracellular matrix formation
por: Wollbold, Johannes, et al.
Publicado: (2009)

Cytokine mRNA and protein expression in primary-culture and repeated-passage synovial fibroblasts from patients with rheumatoid arthritis
por: Hirth, Astrid, et al.
Publicado: (2002)

Association of autophagy to the phenotypic transformation of synovial fibroblasts in rheumatoid arthritis
por: Kondo, Naoki
Publicado: (2022)

Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture — primary culture cells markedly differ from fourth-passage cells
por: Zimmermann, Thomas, et al.
Publicado: (2001)

Mosaic chromosomal aberrations in synovial fibroblasts of patients with rheumatoid arthritis, osteoarthritis, and other inflammatory joint diseases
por: Kinne, Raimund W, et al.
Publicado: (2001)

Activation of Synovial Fibroblasts in Rheumatoid Arthritis
por: Gay, Steffen, et al.
Publicado: (2000)

Molecular discrimination of responders and nonresponders to anti-TNFalpha therapy in rheumatoid arthritis by etanercept
por: Koczan, Dirk, et al.
Publicado: (2008)

Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts
Publicado: (1991)

Kinesin-like protein CENP-E is upregulated in rheumatoid synovial fibroblasts
por: Kullmann , Frank, et al.
Publicado: (1999)

HMGB1–LPS complex promotes transformation of osteoarthritis synovial fibroblasts to a rheumatoid arthritis synovial fibroblast-like phenotype
por: Qin, Y, et al.
Publicado: (2014)

Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts
por: Müller-Ladner, Ulf, et al.
Publicado: (2007)

Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-κB binding activity and TNF-α secretion of T cells
por: Pohlers, Dirk, et al.
Publicado: (2002)

Evidence for synovial fibroblasts spreading rheumatoid arthritis
por: Müller-Ladner, Ulf, et al.
Publicado: (2012)

Multiomics landscape of synovial fibroblasts in rheumatoid arthritis
por: Tsuchiya, Haruka, et al.
Publicado: (2021)

Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis
por: Smith, Melanie H., et al.
Publicado: (2023)

Expression of cytokine mRNA and protein in joints and lymphoid organs during the course of rat antigen-induced arthritis
por: Pohlers, Dirk, et al.
Publicado: (2005)

Fibroblast biology: Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis
por: Pap, Thomas, et al.
Publicado: (2000)

Macrophages in rheumatoid arthritis
por: Kinne, Raimund W, et al.
Publicado: (2000)

IL-33 regulates TNF-α dependent effects in synovial fibroblasts
por: KUNISCH, ELKE, et al.
Publicado: (2012)

Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis
por: Yu, Xinhua, et al.
Publicado: (2007)

Targeting Activated Synovial Fibroblasts in Rheumatoid Arthritis by Peficitinib
por: Diller, Magnus, et al.
Publicado: (2019)

Cytokine expression was assessed during antigen-induced arthritis in the synovial membrane, inguinal lymph node, and spleen using competitive RT-PCR and sandwich ELISA
por: Kinne, RW, et al.
Publicado: (2005)

Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis
por: Akhavani, Mohammed A, et al.
Publicado: (2009)

Gene expression profile and synovial microcirculation at early stages of collagen-induced arthritis
por: Gierer, Philip, et al.
Publicado: (2005)

Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts
por: Suzuki, Kohjin, et al.
Publicado: (2018)

Differential gene expression of proliferating synovial fibroblasts in rheumatoid arthritis
por: Masuda, KM, et al.
Publicado: (2002)

Transcriptional response to hypoxia of normal and rheumatoid arthritis synovial fibroblasts
por: Del Rey, M J, et al.
Publicado: (2010)

The epigenome of synovial fibroblasts: an underestimated therapeutic target in rheumatoid arthritis
por: Frank-Bertoncelj, Mojca, et al.
Publicado: (2014)

Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation
por: Jones, Douglas S., et al.
Publicado: (2016)

Marker Genes Change of Synovial Fibroblasts in Rheumatoid Arthritis Patients
por: Liao, Lifen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_p0td5ih9qn0f62qau9qbmhu0am