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Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes

c-Jun N-terminal kinase (JNK) contributes to metalloproteinase (MMP) gene expression and joint destruction in inflammatory arthritis. It is phosphorylated by at least two upstream kinases, the mitogen-activated protein kinase kinases (MEK) MKK4 and MKK7, which are, in turn, phosphorylated by MEK kin...

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Detalles Bibliográficos
Autores principales:	Hammaker, Deepa R, Boyle, David L, Inoue, Tomoyuki, Firestein, Gary S
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206340/ https://www.ncbi.nlm.nih.gov/pubmed/17559674 http://dx.doi.org/10.1186/ar2215

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