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Cells of the synovium in rheumatoid arthritis. Dendritic cells

Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals that promote...

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Detalles Bibliográficos
Autores principales: Lutzky, Viviana, Hannawi, Suad, Thomas, Ranjeny
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206384/
https://www.ncbi.nlm.nih.gov/pubmed/17850683
http://dx.doi.org/10.1186/ar2200
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author Lutzky, Viviana
Hannawi, Suad
Thomas, Ranjeny
author_facet Lutzky, Viviana
Hannawi, Suad
Thomas, Ranjeny
author_sort Lutzky, Viviana
collection PubMed
description Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals that promote the activation of NF-κB and the secretion of TNF and IL-1 drive the maturation of dendritic cells to prime self-specific responses, and drive the perpetuation of synovial inflammation. These signals may include genetic factors, infection, cigarette smoking, immunostimulatory DNA and oxidized low-density lipoprotein, with major involvement of autoantibodies. We propose that the pathogenesis of RA and atherosclerosis is intimately linked, with the vascular disease of RA driven by similar and simultaneous triggers to NF-κB.
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spelling pubmed-22063842008-01-19 Cells of the synovium in rheumatoid arthritis. Dendritic cells Lutzky, Viviana Hannawi, Suad Thomas, Ranjeny Arthritis Res Ther Review Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals that promote the activation of NF-κB and the secretion of TNF and IL-1 drive the maturation of dendritic cells to prime self-specific responses, and drive the perpetuation of synovial inflammation. These signals may include genetic factors, infection, cigarette smoking, immunostimulatory DNA and oxidized low-density lipoprotein, with major involvement of autoantibodies. We propose that the pathogenesis of RA and atherosclerosis is intimately linked, with the vascular disease of RA driven by similar and simultaneous triggers to NF-κB. BioMed Central 2007 2007-09-07 /pmc/articles/PMC2206384/ /pubmed/17850683 http://dx.doi.org/10.1186/ar2200 Text en Copyright © 2007 BioMed Central Ltd
spellingShingle Review
Lutzky, Viviana
Hannawi, Suad
Thomas, Ranjeny
Cells of the synovium in rheumatoid arthritis. Dendritic cells
title Cells of the synovium in rheumatoid arthritis. Dendritic cells
title_full Cells of the synovium in rheumatoid arthritis. Dendritic cells
title_fullStr Cells of the synovium in rheumatoid arthritis. Dendritic cells
title_full_unstemmed Cells of the synovium in rheumatoid arthritis. Dendritic cells
title_short Cells of the synovium in rheumatoid arthritis. Dendritic cells
title_sort cells of the synovium in rheumatoid arthritis. dendritic cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206384/
https://www.ncbi.nlm.nih.gov/pubmed/17850683
http://dx.doi.org/10.1186/ar2200
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