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Influence of dextran-70 on systemic inflammatory response and myocardial ischaemia-reperfusion following cardiac operations
INTRODUCTION: Experimental studies have demonstrated that dextran-70 reduces the leukocyte–endothelium interaction, but clinical evidence is still lacking. Our objective was to justify the anti-inflammatory effect of dextran-70 following cardiac operations. METHODS: Forty patients undergoing coronar...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206488/ https://www.ncbi.nlm.nih.gov/pubmed/17697359 http://dx.doi.org/10.1186/cc6095 |
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author | Gombocz, Károly Beledi, Ágnes Alotti, Nasri Kecskés, Gábor Gábor, Valéria Bogár, Lajos Kőszegi, Tamás Garai, János |
author_facet | Gombocz, Károly Beledi, Ágnes Alotti, Nasri Kecskés, Gábor Gábor, Valéria Bogár, Lajos Kőszegi, Tamás Garai, János |
author_sort | Gombocz, Károly |
collection | PubMed |
description | INTRODUCTION: Experimental studies have demonstrated that dextran-70 reduces the leukocyte–endothelium interaction, but clinical evidence is still lacking. Our objective was to justify the anti-inflammatory effect of dextran-70 following cardiac operations. METHODS: Forty patients undergoing coronary bypass surgery (n = 32) or aortic valve replacement (n = 8) were enrolled in this prospective, randomized, double-blind study. Two groups were formed. In group A (n = 20), dextran-70 infusion was administered at a dose of 7.5 ml/kg before the initiation of cardiopulmonary bypass and at a dose of 12.5 ml/kg after the cessation of cardiopulmonary bypass. Group B served as a control with identical amounts of gelatin infusion (n = 20). The plasma concentration of procalcitonin, C-reactive protein, IL 6, IL 6r, IL 8, IL 10, soluble endothelial leukocyte adhesion molecule-1, soluble intercellular adhesion molecule-1, cardiac troponin-I and various haemodynamic parameters were measured in the perioperative period. Multivariate methods were used for statistical analysis. RESULTS: In group A, lower peak (median) plasma levels of procalcitonin (0.2 versus 1.4, p < 0.001), IL 8 (5.6 versus 94.8, p < 0.001), IL 10 (47.2 versus 209.7, p = 0.001), endothelial leukocyte adhesion molecule-1 (88.5 versus 130.6, p = 0.033), intercellular adhesion molecule-1 (806.7 versus 1,375.7, P = 0.001) and troponin-I (0.22 versus 0.66, p = 0.018) were found. There was no significant difference in IL 6, IL-6r and C-reactive protein values between groups. Higher figures of the cardiac index (p = 0.010) along with reduced systemic vascular resistance (p = 0.005) were noted in group A. CONCLUSION: Our investigation demonstrated that the use of dextran-70 reduces the systemic inflammatory response and cardiac troponin-I release following cardiac operation. TRIAL REGISTRATION NUMBER: ISRCTN38289094. |
format | Text |
id | pubmed-2206488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-22064882008-01-19 Influence of dextran-70 on systemic inflammatory response and myocardial ischaemia-reperfusion following cardiac operations Gombocz, Károly Beledi, Ágnes Alotti, Nasri Kecskés, Gábor Gábor, Valéria Bogár, Lajos Kőszegi, Tamás Garai, János Crit Care Research INTRODUCTION: Experimental studies have demonstrated that dextran-70 reduces the leukocyte–endothelium interaction, but clinical evidence is still lacking. Our objective was to justify the anti-inflammatory effect of dextran-70 following cardiac operations. METHODS: Forty patients undergoing coronary bypass surgery (n = 32) or aortic valve replacement (n = 8) were enrolled in this prospective, randomized, double-blind study. Two groups were formed. In group A (n = 20), dextran-70 infusion was administered at a dose of 7.5 ml/kg before the initiation of cardiopulmonary bypass and at a dose of 12.5 ml/kg after the cessation of cardiopulmonary bypass. Group B served as a control with identical amounts of gelatin infusion (n = 20). The plasma concentration of procalcitonin, C-reactive protein, IL 6, IL 6r, IL 8, IL 10, soluble endothelial leukocyte adhesion molecule-1, soluble intercellular adhesion molecule-1, cardiac troponin-I and various haemodynamic parameters were measured in the perioperative period. Multivariate methods were used for statistical analysis. RESULTS: In group A, lower peak (median) plasma levels of procalcitonin (0.2 versus 1.4, p < 0.001), IL 8 (5.6 versus 94.8, p < 0.001), IL 10 (47.2 versus 209.7, p = 0.001), endothelial leukocyte adhesion molecule-1 (88.5 versus 130.6, p = 0.033), intercellular adhesion molecule-1 (806.7 versus 1,375.7, P = 0.001) and troponin-I (0.22 versus 0.66, p = 0.018) were found. There was no significant difference in IL 6, IL-6r and C-reactive protein values between groups. Higher figures of the cardiac index (p = 0.010) along with reduced systemic vascular resistance (p = 0.005) were noted in group A. CONCLUSION: Our investigation demonstrated that the use of dextran-70 reduces the systemic inflammatory response and cardiac troponin-I release following cardiac operation. TRIAL REGISTRATION NUMBER: ISRCTN38289094. BioMed Central 2007 2007-08-14 /pmc/articles/PMC2206488/ /pubmed/17697359 http://dx.doi.org/10.1186/cc6095 Text en Copyright © 2007 Gombocz et al., licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Gombocz, Károly Beledi, Ágnes Alotti, Nasri Kecskés, Gábor Gábor, Valéria Bogár, Lajos Kőszegi, Tamás Garai, János Influence of dextran-70 on systemic inflammatory response and myocardial ischaemia-reperfusion following cardiac operations |
title | Influence of dextran-70 on systemic inflammatory response and myocardial ischaemia-reperfusion following cardiac operations |
title_full | Influence of dextran-70 on systemic inflammatory response and myocardial ischaemia-reperfusion following cardiac operations |
title_fullStr | Influence of dextran-70 on systemic inflammatory response and myocardial ischaemia-reperfusion following cardiac operations |
title_full_unstemmed | Influence of dextran-70 on systemic inflammatory response and myocardial ischaemia-reperfusion following cardiac operations |
title_short | Influence of dextran-70 on systemic inflammatory response and myocardial ischaemia-reperfusion following cardiac operations |
title_sort | influence of dextran-70 on systemic inflammatory response and myocardial ischaemia-reperfusion following cardiac operations |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206488/ https://www.ncbi.nlm.nih.gov/pubmed/17697359 http://dx.doi.org/10.1186/cc6095 |
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