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Adenovirus type 5 E1A-induced apoptosis in COX-2-overexpressing breast cancer cells

INTRODUCTION: Suppression of Bcl-2 expression can overcome cellular resistance to apoptosis induced by the adenovirus type 5 gene E1A in models of ovarian and breast cancer. Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, is known to downregulate Bcl-2 expression. We hypothesized that celecoxib wou...

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Detalles Bibliográficos
Autores principales:	Sugimoto, Takeshi, Bartholomeusz, Chandra, Tari, Ana M, Ueno, Naoto T
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206712/ https://www.ncbi.nlm.nih.gov/pubmed/17612393 http://dx.doi.org/10.1186/bcr1739

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