Instability of retroviral vectors with HIV-1-specific RT aptamers due to cryptic splice sites in the U6 promoter

BACKGROUND: Internal polymerase III promoters in retroviral vectors have been used extensively to express short RNA sequences, such as ribozymes, RNA aptamers or short interfering RNA inhibitors, in various positions and orientations. However, the stability of these promoters in the reverse orientat...

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Detalles Bibliográficos
Autores principales: Braun, Stephen E, Shi, Xuanling, Qiu, Gang, Wong, Fay Eng, Joshi, Pheroze J, Prasad, Vinayaka R, Johnson, R Paul
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211285/
https://www.ncbi.nlm.nih.gov/pubmed/17941994
http://dx.doi.org/10.1186/1742-6405-4-24

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