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β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis

β-catenin–mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP–mediated inactivation of the β-catenin gene in bone marrow progenitors does...

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Detalles Bibliográficos
Autores principales: Cobas, Monica, Wilson, Anne, Ernst, Bettina, Mancini, Stéphane J.C., MacDonald, H. Robson, Kemler, Rolf, Radtke, Freddy
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211763/
https://www.ncbi.nlm.nih.gov/pubmed/14718516
http://dx.doi.org/10.1084/jem.20031615
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author Cobas, Monica
Wilson, Anne
Ernst, Bettina
Mancini, Stéphane J.C.
MacDonald, H. Robson
Kemler, Rolf
Radtke, Freddy
author_facet Cobas, Monica
Wilson, Anne
Ernst, Bettina
Mancini, Stéphane J.C.
MacDonald, H. Robson
Kemler, Rolf
Radtke, Freddy
author_sort Cobas, Monica
collection PubMed
description β-catenin–mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP–mediated inactivation of the β-catenin gene in bone marrow progenitors does not impair their ability to self-renew and reconstitute all hematopoietic lineages (myeloid, erythroid, and lymphoid), even in competitive mixed chimeras. In addition, both thymocyte survival and antigen-induced proliferation of peripheral T cells is β-catenin independent. In contrast to earlier reports, these data exclude an essential role for β-catenin during hematopoiesis and lymphopoiesis.
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spelling pubmed-22117632008-03-11 β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis Cobas, Monica Wilson, Anne Ernst, Bettina Mancini, Stéphane J.C. MacDonald, H. Robson Kemler, Rolf Radtke, Freddy J Exp Med Article β-catenin–mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP–mediated inactivation of the β-catenin gene in bone marrow progenitors does not impair their ability to self-renew and reconstitute all hematopoietic lineages (myeloid, erythroid, and lymphoid), even in competitive mixed chimeras. In addition, both thymocyte survival and antigen-induced proliferation of peripheral T cells is β-catenin independent. In contrast to earlier reports, these data exclude an essential role for β-catenin during hematopoiesis and lymphopoiesis. The Rockefeller University Press 2004-01-19 /pmc/articles/PMC2211763/ /pubmed/14718516 http://dx.doi.org/10.1084/jem.20031615 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Cobas, Monica
Wilson, Anne
Ernst, Bettina
Mancini, Stéphane J.C.
MacDonald, H. Robson
Kemler, Rolf
Radtke, Freddy
β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis
title β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis
title_full β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis
title_fullStr β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis
title_full_unstemmed β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis
title_short β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis
title_sort β-catenin is dispensable for hematopoiesis and lymphopoiesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211763/
https://www.ncbi.nlm.nih.gov/pubmed/14718516
http://dx.doi.org/10.1084/jem.20031615
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