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β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis
β-catenin–mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP–mediated inactivation of the β-catenin gene in bone marrow progenitors does...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211763/ https://www.ncbi.nlm.nih.gov/pubmed/14718516 http://dx.doi.org/10.1084/jem.20031615 |
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author | Cobas, Monica Wilson, Anne Ernst, Bettina Mancini, Stéphane J.C. MacDonald, H. Robson Kemler, Rolf Radtke, Freddy |
author_facet | Cobas, Monica Wilson, Anne Ernst, Bettina Mancini, Stéphane J.C. MacDonald, H. Robson Kemler, Rolf Radtke, Freddy |
author_sort | Cobas, Monica |
collection | PubMed |
description | β-catenin–mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP–mediated inactivation of the β-catenin gene in bone marrow progenitors does not impair their ability to self-renew and reconstitute all hematopoietic lineages (myeloid, erythroid, and lymphoid), even in competitive mixed chimeras. In addition, both thymocyte survival and antigen-induced proliferation of peripheral T cells is β-catenin independent. In contrast to earlier reports, these data exclude an essential role for β-catenin during hematopoiesis and lymphopoiesis. |
format | Text |
id | pubmed-2211763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22117632008-03-11 β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis Cobas, Monica Wilson, Anne Ernst, Bettina Mancini, Stéphane J.C. MacDonald, H. Robson Kemler, Rolf Radtke, Freddy J Exp Med Article β-catenin–mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP–mediated inactivation of the β-catenin gene in bone marrow progenitors does not impair their ability to self-renew and reconstitute all hematopoietic lineages (myeloid, erythroid, and lymphoid), even in competitive mixed chimeras. In addition, both thymocyte survival and antigen-induced proliferation of peripheral T cells is β-catenin independent. In contrast to earlier reports, these data exclude an essential role for β-catenin during hematopoiesis and lymphopoiesis. The Rockefeller University Press 2004-01-19 /pmc/articles/PMC2211763/ /pubmed/14718516 http://dx.doi.org/10.1084/jem.20031615 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Cobas, Monica Wilson, Anne Ernst, Bettina Mancini, Stéphane J.C. MacDonald, H. Robson Kemler, Rolf Radtke, Freddy β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis |
title | β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis |
title_full | β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis |
title_fullStr | β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis |
title_full_unstemmed | β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis |
title_short | β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis |
title_sort | β-catenin is dispensable for hematopoiesis and lymphopoiesis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211763/ https://www.ncbi.nlm.nih.gov/pubmed/14718516 http://dx.doi.org/10.1084/jem.20031615 |
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