Differential Efficacy of Caspase Inhibitors on Apoptosis Markers during Sepsis in Rats and Implication for Fractional Inhibition Requirements for Therapeutics

A rodent model of sepsis was used to establish the relationship between caspase inhibition and inhibition of apoptotic cell death in vivo. In this model, thymocyte cell death was blocked by Bcl-2 transgene, indicating that apoptosis was predominantly dependent on the mitochondrial pathway that culmi...

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Detalles Bibliográficos
Autores principales: Méthot, Nathalie, Huang, JingQi, Coulombe, Nathalie, Vaillancourt, John P., Rasper, Dita, Tam, John, Han, Yongxin, Colucci, John, Zamboni, Robert, Xanthoudakis, Steven, Toulmond, Sylvie, Nicholson, Donald W., Roy, Sophie
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211770/
https://www.ncbi.nlm.nih.gov/pubmed/14718517
http://dx.doi.org/10.1084/jem.20031791

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