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Massive Thymic Deletion Results in Systemic Autoimmunity through Elimination of CD4(+) CD25(+) T Regulatory Cells

Incomplete deletion of KRN T cells that recognize the ubiquitously expressed self-antigen glucose-6-phosphate-isomerase (GPI) initiates an anti-GPI autoimmune cascade in K/BxN mice resulting in a humorally mediated arthritis. Transgenic (Tg) expression of a KRN T cell receptor (TCR) agonist under th...

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Detalles Bibliográficos
Autores principales:	Shih, Fei F., Mandik-Nayak, Laura, Wipke, Brian T., Allen, Paul M.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211803/ https://www.ncbi.nlm.nih.gov/pubmed/14744995 http://dx.doi.org/10.1084/jem.20031137

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