Cargando…

Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both?

Human mannose-binding lectin (MBL) recognizes a wide range of microorganisms and triggers the most ancient pathway of complement activation. However, ∼5% of individuals lack functional serum MBL and have not been found to be prone to severe infections in prospective studies. These data suggest that...

Descripción completa

Detalles Bibliográficos
Autores principales: Casanova, Jean-Laurent, Abel, Laurent
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211810/
https://www.ncbi.nlm.nih.gov/pubmed/15148331
http://dx.doi.org/10.1084/jem.20040537
_version_ 1782148559642034176
author Casanova, Jean-Laurent
Abel, Laurent
author_facet Casanova, Jean-Laurent
Abel, Laurent
author_sort Casanova, Jean-Laurent
collection PubMed
description Human mannose-binding lectin (MBL) recognizes a wide range of microorganisms and triggers the most ancient pathway of complement activation. However, ∼5% of individuals lack functional serum MBL and have not been found to be prone to severe infections in prospective studies. These data suggest that human MBL is largely redundant for protective immunity and may even have been subject to counter selection because of a deleterious impact.
format Text
id pubmed-2211810
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-22118102008-03-11 Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both? Casanova, Jean-Laurent Abel, Laurent J Exp Med Commentary Human mannose-binding lectin (MBL) recognizes a wide range of microorganisms and triggers the most ancient pathway of complement activation. However, ∼5% of individuals lack functional serum MBL and have not been found to be prone to severe infections in prospective studies. These data suggest that human MBL is largely redundant for protective immunity and may even have been subject to counter selection because of a deleterious impact. The Rockefeller University Press 2004-05-17 /pmc/articles/PMC2211810/ /pubmed/15148331 http://dx.doi.org/10.1084/jem.20040537 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Casanova, Jean-Laurent
Abel, Laurent
Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both?
title Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both?
title_full Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both?
title_fullStr Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both?
title_full_unstemmed Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both?
title_short Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both?
title_sort human mannose-binding lectin in immunity: friend, foe, or both?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211810/
https://www.ncbi.nlm.nih.gov/pubmed/15148331
http://dx.doi.org/10.1084/jem.20040537
work_keys_str_mv AT casanovajeanlaurent humanmannosebindinglectininimmunityfriendfoeorboth
AT abellaurent humanmannosebindinglectininimmunityfriendfoeorboth