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Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both?
Human mannose-binding lectin (MBL) recognizes a wide range of microorganisms and triggers the most ancient pathway of complement activation. However, ∼5% of individuals lack functional serum MBL and have not been found to be prone to severe infections in prospective studies. These data suggest that...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211810/ https://www.ncbi.nlm.nih.gov/pubmed/15148331 http://dx.doi.org/10.1084/jem.20040537 |
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author | Casanova, Jean-Laurent Abel, Laurent |
author_facet | Casanova, Jean-Laurent Abel, Laurent |
author_sort | Casanova, Jean-Laurent |
collection | PubMed |
description | Human mannose-binding lectin (MBL) recognizes a wide range of microorganisms and triggers the most ancient pathway of complement activation. However, ∼5% of individuals lack functional serum MBL and have not been found to be prone to severe infections in prospective studies. These data suggest that human MBL is largely redundant for protective immunity and may even have been subject to counter selection because of a deleterious impact. |
format | Text |
id | pubmed-2211810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22118102008-03-11 Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both? Casanova, Jean-Laurent Abel, Laurent J Exp Med Commentary Human mannose-binding lectin (MBL) recognizes a wide range of microorganisms and triggers the most ancient pathway of complement activation. However, ∼5% of individuals lack functional serum MBL and have not been found to be prone to severe infections in prospective studies. These data suggest that human MBL is largely redundant for protective immunity and may even have been subject to counter selection because of a deleterious impact. The Rockefeller University Press 2004-05-17 /pmc/articles/PMC2211810/ /pubmed/15148331 http://dx.doi.org/10.1084/jem.20040537 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Commentary Casanova, Jean-Laurent Abel, Laurent Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both? |
title | Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both? |
title_full | Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both? |
title_fullStr | Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both? |
title_full_unstemmed | Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both? |
title_short | Human Mannose-binding Lectin in Immunity: Friend, Foe, or Both? |
title_sort | human mannose-binding lectin in immunity: friend, foe, or both? |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211810/ https://www.ncbi.nlm.nih.gov/pubmed/15148331 http://dx.doi.org/10.1084/jem.20040537 |
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