Epstein-Barr Virus Nuclear Antigen 1: from Immunologically Invisible to a Promising T Cell Target

Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)—the one EBV antigen that is expressed in all EBV-associated malignancies—has long been thought to go undetected by the cell-mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4(+) and CD8(+) T cells, making it...

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Detalles Bibliográficos
Autor principal: Münz, Christian
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211815/
https://www.ncbi.nlm.nih.gov/pubmed/15148332
http://dx.doi.org/10.1084/jem.20040730
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author Münz, Christian
author_facet Münz, Christian
author_sort Münz, Christian
collection PubMed
description Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)—the one EBV antigen that is expressed in all EBV-associated malignancies—has long been thought to go undetected by the cell-mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4(+) and CD8(+) T cells, making it a potential new target for immunotherapy of EBV-related cancers.
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spelling pubmed-22118152008-03-11 Epstein-Barr Virus Nuclear Antigen 1: from Immunologically Invisible to a Promising T Cell Target Münz, Christian J Exp Med Commentary Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)—the one EBV antigen that is expressed in all EBV-associated malignancies—has long been thought to go undetected by the cell-mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4(+) and CD8(+) T cells, making it a potential new target for immunotherapy of EBV-related cancers. The Rockefeller University Press 2004-05-17 /pmc/articles/PMC2211815/ /pubmed/15148332 http://dx.doi.org/10.1084/jem.20040730 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Münz, Christian
Epstein-Barr Virus Nuclear Antigen 1: from Immunologically Invisible to a Promising T Cell Target
title Epstein-Barr Virus Nuclear Antigen 1: from Immunologically Invisible to a Promising T Cell Target
title_full Epstein-Barr Virus Nuclear Antigen 1: from Immunologically Invisible to a Promising T Cell Target
title_fullStr Epstein-Barr Virus Nuclear Antigen 1: from Immunologically Invisible to a Promising T Cell Target
title_full_unstemmed Epstein-Barr Virus Nuclear Antigen 1: from Immunologically Invisible to a Promising T Cell Target
title_short Epstein-Barr Virus Nuclear Antigen 1: from Immunologically Invisible to a Promising T Cell Target
title_sort epstein-barr virus nuclear antigen 1: from immunologically invisible to a promising t cell target
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211815/
https://www.ncbi.nlm.nih.gov/pubmed/15148332
http://dx.doi.org/10.1084/jem.20040730
work_keys_str_mv AT munzchristian epsteinbarrvirusnuclearantigen1fromimmunologicallyinvisibletoapromisingtcelltarget

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