N-linked Glycosylation Is Required for Optimal Function of Kaposi's Sarcoma Herpesvirus–encoded, but Not Cellular, Interleukin 6

Kaposi's sarcoma–associated herpesvirus interleukin-6 (vIL-6) is a structural and functional homologue of the human cytokine IL-6 (hIL-6). hIL-6 and vIL-6 exhibit similar biological functions and both act via the gp130 receptor subunit to activate the Janus tyrosine kinase (JAK)1 and signal tra...

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Detalles Bibliográficos
Autores principales: Dela Cruz, Charles S., Lee, Yoomi, Viswanathan, Srinivas R., El-Guindy, Ayman S., Gerlach, Jennifer, Nikiforow, Sarah, Shedd, Duane, Gradoville, Lyn, Miller, George
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211829/
https://www.ncbi.nlm.nih.gov/pubmed/14970177
http://dx.doi.org/10.1084/jem.20031205

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