NK Cells and Trophoblasts: Partners in Pregnancy

In placental mammals, viviparity—the production of living young within the mother's body—evolved under the auspices of the immune system. Elements of immunity were incorporated, giving pregnancy a mildly inflammatory character. Formation of the placenta, the organ that feeds the fetus, involves...

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Detalles Bibliográficos
Autor principal: Parham, Peter
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211836/
https://www.ncbi.nlm.nih.gov/pubmed/15492121
http://dx.doi.org/10.1084/jem.20041783
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author Parham, Peter
author_facet Parham, Peter
author_sort Parham, Peter
collection PubMed
description In placental mammals, viviparity—the production of living young within the mother's body—evolved under the auspices of the immune system. Elements of immunity were incorporated, giving pregnancy a mildly inflammatory character. Formation of the placenta, the organ that feeds the fetus, involves a cooperation between maternal natural killer (NK) cells and fetal trophoblast cells that remodels the blood supply. Recent research reveals that this process and human reproductive success are influenced by polymorphic HLA-C ligands and their killer cell immunoglobulin-like receptors (KIR).
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spelling pubmed-22118362008-03-11 NK Cells and Trophoblasts: Partners in Pregnancy Parham, Peter J Exp Med Commentary In placental mammals, viviparity—the production of living young within the mother's body—evolved under the auspices of the immune system. Elements of immunity were incorporated, giving pregnancy a mildly inflammatory character. Formation of the placenta, the organ that feeds the fetus, involves a cooperation between maternal natural killer (NK) cells and fetal trophoblast cells that remodels the blood supply. Recent research reveals that this process and human reproductive success are influenced by polymorphic HLA-C ligands and their killer cell immunoglobulin-like receptors (KIR). The Rockefeller University Press 2004-10-18 /pmc/articles/PMC2211836/ /pubmed/15492121 http://dx.doi.org/10.1084/jem.20041783 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Parham, Peter
NK Cells and Trophoblasts: Partners in Pregnancy
title NK Cells and Trophoblasts: Partners in Pregnancy
title_full NK Cells and Trophoblasts: Partners in Pregnancy
title_fullStr NK Cells and Trophoblasts: Partners in Pregnancy
title_full_unstemmed NK Cells and Trophoblasts: Partners in Pregnancy
title_short NK Cells and Trophoblasts: Partners in Pregnancy
title_sort nk cells and trophoblasts: partners in pregnancy
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211836/
https://www.ncbi.nlm.nih.gov/pubmed/15492121
http://dx.doi.org/10.1084/jem.20041783
work_keys_str_mv AT parhampeter nkcellsandtrophoblastspartnersinpregnancy

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