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Important Roles for E Protein Binding Sites within the Immunoglobulin κ Chain Intronic Enhancer in Activating V(κ) J(κ) Rearrangement

The immunoglobulin κ light chain intronic enhancer (iE(κ)) activates κ rearrangement and is required to maintain the earlier or more efficient rearrangement of κ versus lambda (λ). To understand the mechanism of how iE(κ) regulates κ rearrangement, we employed homologous recombination to mutate indi...

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Detalles Bibliográficos
Autores principales:	Inlay, Matthew A., Tian, Hua, Lin, Tongxiang, Xu, Yang
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211861/ https://www.ncbi.nlm.nih.gov/pubmed/15504821 http://dx.doi.org/10.1084/jem.20041135

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