NF-κB and the Immunoglobulin κ Gene Enhancer

Enhancers regulate lineage choice and the developmental timing of antigen receptor gene rearrangements. The transcription factor NF-κB has been implicated as a key component of the recombination and transcription activation potential of the immunoglobulin κ chain gene intronic enhancer. Here, I disc...

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Detalles Bibliográficos
Autor principal: Sen, Ranjan
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211865/
https://www.ncbi.nlm.nih.gov/pubmed/15520242
http://dx.doi.org/10.1084/jem.20041255
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author Sen, Ranjan
author_facet Sen, Ranjan
author_sort Sen, Ranjan
collection PubMed
description Enhancers regulate lineage choice and the developmental timing of antigen receptor gene rearrangements. The transcription factor NF-κB has been implicated as a key component of the recombination and transcription activation potential of the immunoglobulin κ chain gene intronic enhancer. Here, I discuss the implications of the new observation that an NF-κB binding site–mutated enhancer in the correct biological context does not appear to affect κgene expression.
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spelling pubmed-22118652008-03-11 NF-κB and the Immunoglobulin κ Gene Enhancer Sen, Ranjan J Exp Med Commentary Enhancers regulate lineage choice and the developmental timing of antigen receptor gene rearrangements. The transcription factor NF-κB has been implicated as a key component of the recombination and transcription activation potential of the immunoglobulin κ chain gene intronic enhancer. Here, I discuss the implications of the new observation that an NF-κB binding site–mutated enhancer in the correct biological context does not appear to affect κgene expression. The Rockefeller University Press 2004-11-01 /pmc/articles/PMC2211865/ /pubmed/15520242 http://dx.doi.org/10.1084/jem.20041255 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Sen, Ranjan
NF-κB and the Immunoglobulin κ Gene Enhancer
title NF-κB and the Immunoglobulin κ Gene Enhancer
title_full NF-κB and the Immunoglobulin κ Gene Enhancer
title_fullStr NF-κB and the Immunoglobulin κ Gene Enhancer
title_full_unstemmed NF-κB and the Immunoglobulin κ Gene Enhancer
title_short NF-κB and the Immunoglobulin κ Gene Enhancer
title_sort nf-κb and the immunoglobulin κ gene enhancer
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211865/
https://www.ncbi.nlm.nih.gov/pubmed/15520242
http://dx.doi.org/10.1084/jem.20041255
work_keys_str_mv AT senranjan nfkbandtheimmunoglobulinkgeneenhancer

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