Cargando…

PML–RARA-RXR Oligomers Mediate Retinoid and Rexinoid/cAMP Cross-Talk in Acute Promyelocytic Leukemia Cell Differentiation

PML–RARA was proposed to initiate acute promyelocytic leukemia (APL) through PML–RARA homodimer–triggered repression. Here, we examined the nature of the PML–RARA protein complex and of its DNA targets in APL cells. Using a selection/amplification approach, we demonstrate that PML–RARA targets consi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kamashev, Dmitrii, Vitoux, Dominique, de Thé, Hugues
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211888/ https://www.ncbi.nlm.nih.gov/pubmed/15096541 http://dx.doi.org/10.1084/jem.20032226

Ejemplares similares

Educational Case: Acute Promyelocytic Leukemia With PML-RARA
por: Kunak, Rebecca L., et al.
Publicado: (2019)

Oral retinoids and rexinoids in cutaneous T-cell lymphomas
por: Sokołowska-Wojdyło, Małgorzata, et al.
Publicado: (2013)

Molecular methods for genomic analyses of variant PML-RARA or other RARA-related chromosomal translocations in acute promyelocytic leukemia
por: Kim, Min Jin, et al.
Publicado: (2012)

Characterization of cryptic rearrangements, deletion, complex variants of PML, RARA in acute promyelocytic leukemia
por: Amare, Pratibha Kadam, et al.
Publicado: (2011)

The PML-RARA fusion is not detectable in historical blood samples of acute promyelocytic leukaemia patients
por: Dunn, William G., et al.
Publicado: (2021)

HNRNPC-RARA Fusion Gene in a Case with Acute Promyelocytic Leukemia Lacking PML-RARA Rearrangement Presenting with Abundant Hemophagocytosis
por: Tan, Jing, et al.
Publicado: (2023)

Absence of natural intracellular retinoids in mouse bone marrow cells and implications for PML-RARA transformation
por: Niu, H, et al.
Publicado: (2015)

Expression and Function of PML-RARA in the Hematopoietic Progenitor Cells of Ctsg-PML-RARA Mice
por: Wartman, Lukas D., et al.
Publicado: (2012)

RXRα ligand Z-10 induces PML-RARα cleavage and APL cell apoptosis through disrupting PML-RARα/RXRα complex in a cAMP-independent manner
por: Xu, Lin, et al.
Publicado: (2017)

Absolute quantification of the pretreatment PML-RARA transcript defines the relapse risk in acute promyelocytic leukemia
por: Albano, Francesco, et al.
Publicado: (2015)

Cytogenetically cryptic PML::RARA fusion in acute promyelocytic leukemia: Testing strategies in the modern era
por: Karlin, Kirill, et al.
Publicado: (2022)

In Vivo Activation of cAMP Signaling Induces Growth Arrest and Differentiation in Acute Promyelocytic Leukemia
por: Guillemin, Marie-Claude, et al.
Publicado: (2002)

Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia
por: dos Santos, Guilherme Augusto, et al.
Publicado: (2013)

The DNA Binding Property of PML/RARA but Not the Integrity of PML Nuclear Bodies Is Indispensable for Leukemic Transformation
por: Liu, Xi, et al.
Publicado: (2014)

FISH Detection of PML-RARA Fusion in ins(15;17) Acute Promyelocytic Leukaemia Depends on Probe Size
por: Campbell, Lynda J., et al.
Publicado: (2013)

High-Risk Microgranular Acute Promyelocytic Leukemia with a Five-Way Complex Translocation Involving PML-RARA
por: Powers, Benjamin, et al.
Publicado: (2015)

Identification of the novel deletion-type PML-RARA mutation associated with the retinoic acid resistance in acute promyelocytic leukemia
por: Hattori, Hikaru, et al.
Publicado: (2018)

PML-RARA Fusion Transcripts Detectable 8 Months prior to Promyelocytic Blast Crisis in Chronic Myeloid Leukemia
por: Wolanin, Stephanie, et al.
Publicado: (2020)

Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene
por: Liquori, Alessandro, et al.
Publicado: (2020)

PML/RARa Interferes with NRF2 Transcriptional Activity Increasing the Sensitivity to Ascorbate of Acute Promyelocytic Leukemia Cells
por: Banella, Cristina, et al.
Publicado: (2019)

Chromosomal abnormality of acute promyelocytic leukemia other than PML-RARA: a case report of acute promyelocytic leukemia with del(5q)
por: Imataki, Osamu, et al.
Publicado: (2016)

Flow cytometric immunobead assay for fast and easy detection of PML–RARA fusion proteins for the diagnosis of acute promyelocytic leukemia
por: Dekking, E H A, et al.
Publicado: (2012)

Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia
por: Villiers, William, et al.
Publicado: (2023)

Acute promyelocytic leukemia with a cryptic insertion of RARA into PML on chromosome 15 due to uniparental isodisomy: A case report
por: Venci, Anna, et al.
Publicado: (2017)

Case Report: Co-existence of a novel EXOC4‐TRHDE gene fusion with PML-RARA in acute promyelocytic leukemia
por: Liu, Xiaodong, et al.
Publicado: (2023)

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA
por: Jaffray, Ellis G., et al.
Publicado: (2023)

Acute promyelocytic leukemia, arsenic, and PML bodies
por: de Thé, Hugues, et al.
Publicado: (2012)

PML-RARα interaction with TRIB3 impedes PPARγ/RXR function and triggers dyslipidemia in acute promyelocytic leukemia
por: Li, Ke, et al.
Publicado: (2020)

Early Detection of t(8;21) Chromosomal Translocations During Treatment of PML-RARA Positive Acute Promyelocytic Leukemia: A Case Study
por: Neto, Walter Kleine, et al.
Publicado: (2010)

The increased expression of 14q32 small nucleolar RNA transcripts in promyelocytic leukemia cells is not dependent on PML–RARA fusion gene
por: Cohen, Y, et al.
Publicado: (2012)

PML-RARA mutations confer varying arsenic trioxide resistance
por: Bai, Dong-Mei, et al.
Publicado: (2016)

A complex translocation (1;17;15) with spliced short-type PML-RARA fusion transcripts in acute promyelocytic leukemia: A case report
por: Lv, Lili, et al.
Publicado: (2019)

Development of Flow Cytometry-Fluorescent In Situ Hybridization (Flow-FISH) Method for Detection of PML/RARa Chromosomal Translocation in Acute Promyelocytic Leukemia Cell Line
por: Zahedipour, Fatemeh, et al.
Publicado: (2017)

Cinobufagin induces acute promyelocytic leukaemia cell apoptosis and PML-RARA degradation in a caspase-dependent manner by inhibiting the β-catenin signalling pathway
por: Bian, Yaoyao, et al.
Publicado: (2022)

Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection
por: Ribet, David, et al.
Publicado: (2017)

Development and Validation of a 3-Plex RT-qPCR Assay for the Simultaneous Detection and Quantitation of the Three PML-RARa Fusion Transcripts in Acute Promyelocytic Leukemia
por: Chen, Zhanguo, et al.
Publicado: (2015)

Adefovir dipivoxil inhibits APL progression through degradation of the oncoprotein PML-RARA
por: Gong, Xubo, et al.
Publicado: (2022)

cFos Mediates cAMP-Dependent Generation of ROS and Rescue of Maturation Program in Retinoid-Resistant Acute Promyelocytic Leukemia Cell Line NB4-LR1
por: Carrier, Jean-Luc, et al.
Publicado: (2012)

Correction: Liquori et al. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624
por: Liquori, Alessandro, et al.
Publicado: (2021)

Connexins and cAMP Cross-Talk in Cancer Progression and Metastasis
por: Chen, Chang-Xu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4j2n9m1g8ovgive0jebdsfhe5e