SLAM Family Receptors Regulate Immunity with and without SAP-related Adaptors

Two papers describing mice deficient in signaling lymphocyte activation molecule and 2B4 represent the first accounts of immune phenotypes in animals lacking members of the SLAM family of receptors. The findings provide definitive evidence of the importance of SLAM-related receptors in the regulatio...

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Detalles Bibliográficos
Autor principal: Veillette, André
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211906/
https://www.ncbi.nlm.nih.gov/pubmed/15123741
http://dx.doi.org/10.1084/jem.20040588
Descripción
Sumario:Two papers describing mice deficient in signaling lymphocyte activation molecule and 2B4 represent the first accounts of immune phenotypes in animals lacking members of the SLAM family of receptors. The findings provide definitive evidence of the importance of SLAM-related receptors in the regulation of T cell, macrophage, and natural killer cell functions.

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