The Ins and Outs of CCR7 in the Thymus

Although it is widely supposed that chemokines play a role in the thymus, most existing evidence is circumstantial. In this issue, two groups provide direct evidence that the chemokine receptor CCR7 is required for normal thymocyte migration (Ueno, T., F. Saito, D. Gray, S. Kuse, K. Hieshima, H. Nak...

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Detalles Bibliográficos
Autores principales: Witt, Colleen M., Robey, Ellen A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211929/
https://www.ncbi.nlm.nih.gov/pubmed/15314071
http://dx.doi.org/10.1084/jem.20041110
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author Witt, Colleen M.
Robey, Ellen A.
author_facet Witt, Colleen M.
Robey, Ellen A.
author_sort Witt, Colleen M.
collection PubMed
description Although it is widely supposed that chemokines play a role in the thymus, most existing evidence is circumstantial. In this issue, two groups provide direct evidence that the chemokine receptor CCR7 is required for normal thymocyte migration (Ueno, T., F. Saito, D. Gray, S. Kuse, K. Hieshima, H. Nakano, T. Kakiuchi, M. Lipp, R. Boyd, and Y. Takahama. 2004. J. Exp. Med. 200:493–505; Misslitz, A., O. Pabst, G. Hintzen, L. Ohl, E. Kremmer, H. T. Petrie, and R. Forster. 2004. J. Exp. Med. 200:481–491). The two papers focus on distinct and opposite migration events, an early outward migration and a later inward migration. Together these papers provide a fascinating picture of the complex role of CCR7 in orchestrating thymocyte migration.
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spelling pubmed-22119292008-03-11 The Ins and Outs of CCR7 in the Thymus Witt, Colleen M. Robey, Ellen A. J Exp Med Commentary Although it is widely supposed that chemokines play a role in the thymus, most existing evidence is circumstantial. In this issue, two groups provide direct evidence that the chemokine receptor CCR7 is required for normal thymocyte migration (Ueno, T., F. Saito, D. Gray, S. Kuse, K. Hieshima, H. Nakano, T. Kakiuchi, M. Lipp, R. Boyd, and Y. Takahama. 2004. J. Exp. Med. 200:493–505; Misslitz, A., O. Pabst, G. Hintzen, L. Ohl, E. Kremmer, H. T. Petrie, and R. Forster. 2004. J. Exp. Med. 200:481–491). The two papers focus on distinct and opposite migration events, an early outward migration and a later inward migration. Together these papers provide a fascinating picture of the complex role of CCR7 in orchestrating thymocyte migration. The Rockefeller University Press 2004-08-16 /pmc/articles/PMC2211929/ /pubmed/15314071 http://dx.doi.org/10.1084/jem.20041110 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Witt, Colleen M.
Robey, Ellen A.
The Ins and Outs of CCR7 in the Thymus
title The Ins and Outs of CCR7 in the Thymus
title_full The Ins and Outs of CCR7 in the Thymus
title_fullStr The Ins and Outs of CCR7 in the Thymus
title_full_unstemmed The Ins and Outs of CCR7 in the Thymus
title_short The Ins and Outs of CCR7 in the Thymus
title_sort ins and outs of ccr7 in the thymus
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211929/
https://www.ncbi.nlm.nih.gov/pubmed/15314071
http://dx.doi.org/10.1084/jem.20041110
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