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SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice

Rapid clearance of pathogens is essential for successful control of pyogenic bacterial infection. Previous experiments have shown that antibody to specific intracellular adhesion molecule-grabbing nonintegrin (SIGN)-R1 inhibits uptake of capsular polysaccharide by marginal zone macrophages, suggesti...

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Autores principales: Lanoue, Astrid, Clatworthy, Menna R., Smith, Philippa, Green, Sheila, Townsend, Michael J., Jolin, Helen E., Smith, Kenneth G.C., Fallon, Padraic G., McKenzie, Andrew N.J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211941/
https://www.ncbi.nlm.nih.gov/pubmed/15583012
http://dx.doi.org/10.1084/jem.20040795
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author Lanoue, Astrid
Clatworthy, Menna R.
Smith, Philippa
Green, Sheila
Townsend, Michael J.
Jolin, Helen E.
Smith, Kenneth G.C.
Fallon, Padraic G.
McKenzie, Andrew N.J.
author_facet Lanoue, Astrid
Clatworthy, Menna R.
Smith, Philippa
Green, Sheila
Townsend, Michael J.
Jolin, Helen E.
Smith, Kenneth G.C.
Fallon, Padraic G.
McKenzie, Andrew N.J.
author_sort Lanoue, Astrid
collection PubMed
description Rapid clearance of pathogens is essential for successful control of pyogenic bacterial infection. Previous experiments have shown that antibody to specific intracellular adhesion molecule-grabbing nonintegrin (SIGN)-R1 inhibits uptake of capsular polysaccharide by marginal zone macrophages, suggesting a role for SIGN-R1 in this process. We now demonstrate that mice lacking SIGN-R1 (a mouse homologue of human dendritic cell–SIGN receptor) are significantly more susceptible to Streptococcus pneumoniae infection and fail to clear S. pneumoniae from the circulation. Marginal zone and peritoneal macrophages show impaired bacterial recognition associated with an inability to bind T-independent type 2 antigens such as dextran. Our work represents the first evidence for a protective in vivo role for a SIGN family molecule.
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spelling pubmed-22119412008-03-11 SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice Lanoue, Astrid Clatworthy, Menna R. Smith, Philippa Green, Sheila Townsend, Michael J. Jolin, Helen E. Smith, Kenneth G.C. Fallon, Padraic G. McKenzie, Andrew N.J. J Exp Med Article Rapid clearance of pathogens is essential for successful control of pyogenic bacterial infection. Previous experiments have shown that antibody to specific intracellular adhesion molecule-grabbing nonintegrin (SIGN)-R1 inhibits uptake of capsular polysaccharide by marginal zone macrophages, suggesting a role for SIGN-R1 in this process. We now demonstrate that mice lacking SIGN-R1 (a mouse homologue of human dendritic cell–SIGN receptor) are significantly more susceptible to Streptococcus pneumoniae infection and fail to clear S. pneumoniae from the circulation. Marginal zone and peritoneal macrophages show impaired bacterial recognition associated with an inability to bind T-independent type 2 antigens such as dextran. Our work represents the first evidence for a protective in vivo role for a SIGN family molecule. The Rockefeller University Press 2004-12-06 /pmc/articles/PMC2211941/ /pubmed/15583012 http://dx.doi.org/10.1084/jem.20040795 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Lanoue, Astrid
Clatworthy, Menna R.
Smith, Philippa
Green, Sheila
Townsend, Michael J.
Jolin, Helen E.
Smith, Kenneth G.C.
Fallon, Padraic G.
McKenzie, Andrew N.J.
SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice
title SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice
title_full SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice
title_fullStr SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice
title_full_unstemmed SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice
title_short SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice
title_sort sign-r1 contributes to protection against lethal pneumococcal infection in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211941/
https://www.ncbi.nlm.nih.gov/pubmed/15583012
http://dx.doi.org/10.1084/jem.20040795
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