Cargando…
SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice
Rapid clearance of pathogens is essential for successful control of pyogenic bacterial infection. Previous experiments have shown that antibody to specific intracellular adhesion molecule-grabbing nonintegrin (SIGN)-R1 inhibits uptake of capsular polysaccharide by marginal zone macrophages, suggesti...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2004
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211941/ https://www.ncbi.nlm.nih.gov/pubmed/15583012 http://dx.doi.org/10.1084/jem.20040795 |
_version_ | 1782148588149669888 |
---|---|
author | Lanoue, Astrid Clatworthy, Menna R. Smith, Philippa Green, Sheila Townsend, Michael J. Jolin, Helen E. Smith, Kenneth G.C. Fallon, Padraic G. McKenzie, Andrew N.J. |
author_facet | Lanoue, Astrid Clatworthy, Menna R. Smith, Philippa Green, Sheila Townsend, Michael J. Jolin, Helen E. Smith, Kenneth G.C. Fallon, Padraic G. McKenzie, Andrew N.J. |
author_sort | Lanoue, Astrid |
collection | PubMed |
description | Rapid clearance of pathogens is essential for successful control of pyogenic bacterial infection. Previous experiments have shown that antibody to specific intracellular adhesion molecule-grabbing nonintegrin (SIGN)-R1 inhibits uptake of capsular polysaccharide by marginal zone macrophages, suggesting a role for SIGN-R1 in this process. We now demonstrate that mice lacking SIGN-R1 (a mouse homologue of human dendritic cell–SIGN receptor) are significantly more susceptible to Streptococcus pneumoniae infection and fail to clear S. pneumoniae from the circulation. Marginal zone and peritoneal macrophages show impaired bacterial recognition associated with an inability to bind T-independent type 2 antigens such as dextran. Our work represents the first evidence for a protective in vivo role for a SIGN family molecule. |
format | Text |
id | pubmed-2211941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22119412008-03-11 SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice Lanoue, Astrid Clatworthy, Menna R. Smith, Philippa Green, Sheila Townsend, Michael J. Jolin, Helen E. Smith, Kenneth G.C. Fallon, Padraic G. McKenzie, Andrew N.J. J Exp Med Article Rapid clearance of pathogens is essential for successful control of pyogenic bacterial infection. Previous experiments have shown that antibody to specific intracellular adhesion molecule-grabbing nonintegrin (SIGN)-R1 inhibits uptake of capsular polysaccharide by marginal zone macrophages, suggesting a role for SIGN-R1 in this process. We now demonstrate that mice lacking SIGN-R1 (a mouse homologue of human dendritic cell–SIGN receptor) are significantly more susceptible to Streptococcus pneumoniae infection and fail to clear S. pneumoniae from the circulation. Marginal zone and peritoneal macrophages show impaired bacterial recognition associated with an inability to bind T-independent type 2 antigens such as dextran. Our work represents the first evidence for a protective in vivo role for a SIGN family molecule. The Rockefeller University Press 2004-12-06 /pmc/articles/PMC2211941/ /pubmed/15583012 http://dx.doi.org/10.1084/jem.20040795 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Lanoue, Astrid Clatworthy, Menna R. Smith, Philippa Green, Sheila Townsend, Michael J. Jolin, Helen E. Smith, Kenneth G.C. Fallon, Padraic G. McKenzie, Andrew N.J. SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice |
title | SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice |
title_full | SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice |
title_fullStr | SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice |
title_full_unstemmed | SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice |
title_short | SIGN-R1 Contributes to Protection against Lethal Pneumococcal Infection in Mice |
title_sort | sign-r1 contributes to protection against lethal pneumococcal infection in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211941/ https://www.ncbi.nlm.nih.gov/pubmed/15583012 http://dx.doi.org/10.1084/jem.20040795 |
work_keys_str_mv | AT lanoueastrid signr1contributestoprotectionagainstlethalpneumococcalinfectioninmice AT clatworthymennar signr1contributestoprotectionagainstlethalpneumococcalinfectioninmice AT smithphilippa signr1contributestoprotectionagainstlethalpneumococcalinfectioninmice AT greensheila signr1contributestoprotectionagainstlethalpneumococcalinfectioninmice AT townsendmichaelj signr1contributestoprotectionagainstlethalpneumococcalinfectioninmice AT jolinhelene signr1contributestoprotectionagainstlethalpneumococcalinfectioninmice AT smithkennethgc signr1contributestoprotectionagainstlethalpneumococcalinfectioninmice AT fallonpadraicg signr1contributestoprotectionagainstlethalpneumococcalinfectioninmice AT mckenzieandrewnj signr1contributestoprotectionagainstlethalpneumococcalinfectioninmice |