Evidence for Selective Transformation of Autoreactive Immature Plasma Cells in Mice Deficient in Fasl

Germline mutations in Fas and Fasl induce nonmalignant T cell hyperplasia and systemic autoimmunity and also greatly increase the risk of B cell neoplasms. B lymphomas occurring in Fasl mutant (gld) mice usually are immunoglobulin (Ig) isotype switched, secrete Ig, and are plasmacytoid in appearance...

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Detalles Bibliográficos
Autores principales: Zhang, Jian Qiao, Okumura, Cheryl, McCarty, Thomas, Shin, Min Sun, Mukhopadhyay, Partha, Hori, Mitsuo, Torrey, Ted A., Naghashfar, Zohreh, Zhou, Jeff X., Lee, Chang Hoon, Roopenian, Derry C., Morse, Herbert C., Davidson, Wendy F.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211944/
https://www.ncbi.nlm.nih.gov/pubmed/15583018
http://dx.doi.org/10.1084/jem.20041575

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