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Centromeric Repositioning of Coreceptor Loci Predicts Their Stable Silencing and the CD4/CD8 Lineage Choice

The differentiation of CD4(+) CD8(+) double positive (DP) thymocytes requires the irreversible choice between two alternative lineages, distinguished by the mutually exclusive expression of either CD4 or CD8. Differentiating DP cells transiently down-regulate both CD4 and CD8, and this has complicat...

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Detalles Bibliográficos
Autores principales:	Merkenschlager, Matthias, Amoils, Shannon, Roldan, Esther, Rahemtulla, Amin, O'Connor, Eric, Fisher, Amanda G., Brown, Karen E.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211953/ https://www.ncbi.nlm.nih.gov/pubmed/15583016 http://dx.doi.org/10.1084/jem.20041127

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