Getting to the Guts of HIV Pathogenesis

Two groups have shown that, as in macaques infected with simian immunodeficiency virus (SIV), intestinal CD4(+) T cells are selectively and rapidly depleted in the intestine of HIV-infected patients. Depletion of intestinal CD4(+) T cells occurred at all stages of infection regardless of highly acti...

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Detalles Bibliográficos
Autores principales: Veazey, Ronald S., Lackner, Andrew A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211972/
https://www.ncbi.nlm.nih.gov/pubmed/15381725
http://dx.doi.org/10.1084/jem.20041464
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author Veazey, Ronald S.
Lackner, Andrew A.
author_facet Veazey, Ronald S.
Lackner, Andrew A.
author_sort Veazey, Ronald S.
collection PubMed
description Two groups have shown that, as in macaques infected with simian immunodeficiency virus (SIV), intestinal CD4(+) T cells are selectively and rapidly depleted in the intestine of HIV-infected patients. Depletion of intestinal CD4(+) T cells occurred at all stages of infection regardless of highly active antiretroviral therapy (HAART). Here we discuss the important implications of these papers for our understanding of HIV pathogenesis, treatment, and vaccine design.
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spelling pubmed-22119722008-03-11 Getting to the Guts of HIV Pathogenesis Veazey, Ronald S. Lackner, Andrew A. J Exp Med Commentary Two groups have shown that, as in macaques infected with simian immunodeficiency virus (SIV), intestinal CD4(+) T cells are selectively and rapidly depleted in the intestine of HIV-infected patients. Depletion of intestinal CD4(+) T cells occurred at all stages of infection regardless of highly active antiretroviral therapy (HAART). Here we discuss the important implications of these papers for our understanding of HIV pathogenesis, treatment, and vaccine design. The Rockefeller University Press 2004-09-20 /pmc/articles/PMC2211972/ /pubmed/15381725 http://dx.doi.org/10.1084/jem.20041464 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Veazey, Ronald S.
Lackner, Andrew A.
Getting to the Guts of HIV Pathogenesis
title Getting to the Guts of HIV Pathogenesis
title_full Getting to the Guts of HIV Pathogenesis
title_fullStr Getting to the Guts of HIV Pathogenesis
title_full_unstemmed Getting to the Guts of HIV Pathogenesis
title_short Getting to the Guts of HIV Pathogenesis
title_sort getting to the guts of hiv pathogenesis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211972/
https://www.ncbi.nlm.nih.gov/pubmed/15381725
http://dx.doi.org/10.1084/jem.20041464
work_keys_str_mv AT veazeyronalds gettingtothegutsofhivpathogenesis
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