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A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation

Dendritic cells (DCs) play a predominant role in activation of natural killer (NK) cells that exert their functions against pathogen-infected and tumor cells. Here, we used a murine model to investigate the molecular mechanisms responsible for this process. Two soluble molecules produced by bacteria...

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Autores principales: Granucci, Francesca, Zanoni, Ivan, Pavelka, Norman, van Dommelen, Serani L.H., Andoniou, Christopher E., Belardelli, Filippo, Degli Esposti, Mariapia A., Ricciardi-Castagnoli, Paola
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211974/
https://www.ncbi.nlm.nih.gov/pubmed/15289500
http://dx.doi.org/10.1084/jem.20040370
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author Granucci, Francesca
Zanoni, Ivan
Pavelka, Norman
van Dommelen, Serani L.H.
Andoniou, Christopher E.
Belardelli, Filippo
Degli Esposti, Mariapia A.
Ricciardi-Castagnoli, Paola
author_facet Granucci, Francesca
Zanoni, Ivan
Pavelka, Norman
van Dommelen, Serani L.H.
Andoniou, Christopher E.
Belardelli, Filippo
Degli Esposti, Mariapia A.
Ricciardi-Castagnoli, Paola
author_sort Granucci, Francesca
collection PubMed
description Dendritic cells (DCs) play a predominant role in activation of natural killer (NK) cells that exert their functions against pathogen-infected and tumor cells. Here, we used a murine model to investigate the molecular mechanisms responsible for this process. Two soluble molecules produced by bacterially activated myeloid DCs are required for optimal priming of NK cells. Type I interferons (IFNs) promote the cytotoxic functions of NK cells. IL-2 is necessary both in vitro and in vivo for the efficient production of IFNγ, which has an important antimetastatic and antibacterial function. These findings provide new information about the mechanisms that mediate DC–NK cell interactions and define a novel and fundamental role for IL-2 in innate immunity.
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spelling pubmed-22119742008-03-11 A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation Granucci, Francesca Zanoni, Ivan Pavelka, Norman van Dommelen, Serani L.H. Andoniou, Christopher E. Belardelli, Filippo Degli Esposti, Mariapia A. Ricciardi-Castagnoli, Paola J Exp Med Article Dendritic cells (DCs) play a predominant role in activation of natural killer (NK) cells that exert their functions against pathogen-infected and tumor cells. Here, we used a murine model to investigate the molecular mechanisms responsible for this process. Two soluble molecules produced by bacterially activated myeloid DCs are required for optimal priming of NK cells. Type I interferons (IFNs) promote the cytotoxic functions of NK cells. IL-2 is necessary both in vitro and in vivo for the efficient production of IFNγ, which has an important antimetastatic and antibacterial function. These findings provide new information about the mechanisms that mediate DC–NK cell interactions and define a novel and fundamental role for IL-2 in innate immunity. The Rockefeller University Press 2004-08-02 /pmc/articles/PMC2211974/ /pubmed/15289500 http://dx.doi.org/10.1084/jem.20040370 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Granucci, Francesca
Zanoni, Ivan
Pavelka, Norman
van Dommelen, Serani L.H.
Andoniou, Christopher E.
Belardelli, Filippo
Degli Esposti, Mariapia A.
Ricciardi-Castagnoli, Paola
A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation
title A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation
title_full A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation
title_fullStr A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation
title_full_unstemmed A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation
title_short A Contribution of Mouse Dendritic Cell–Derived IL-2 for NK Cell Activation
title_sort contribution of mouse dendritic cell–derived il-2 for nk cell activation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211974/
https://www.ncbi.nlm.nih.gov/pubmed/15289500
http://dx.doi.org/10.1084/jem.20040370
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