Cargando…

Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

Regulatory T cells have been clearly implicated in the control of disease in murine models of autoimmunity. The paucity of data regarding the role of these lymphocytes in human autoimmune disease has prompted us to examine their function in patients with rheumatoid arthritis (RA). Regulatory (CD4(+)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ehrenstein, Michael R., Evans, Jamie G., Singh, Animesh, Moore, Samantha, Warnes, Gary, Isenberg, David A., Mauri, Claudia
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211983/ https://www.ncbi.nlm.nih.gov/pubmed/15280421 http://dx.doi.org/10.1084/jem.20040165

Ejemplares similares

Anti-TNF antibody therapy induces IL-17 suppressing regulatory T cells in patients with rheumatoid arthritis
por: McGovern, Jenny, et al.
Publicado: (2012)

Anti–TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β
por: Nadkarni, Suchita, et al.
Publicado: (2007)

Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF–TNF-RII binding in rheumatoid arthritis
por: Nguyen, Dao Xuan, et al.
Publicado: (2016)

The role of TNF-α in rheumatoid arthritis: a focus on regulatory T cells
por: Farrugia, Mark, et al.
Publicado: (2016)

Regulatory T cells enhance Th17 migration in psoriatic arthritis which is reversed by anti-TNF
por: Nguyen, Dao X., et al.
Publicado: (2021)

Cells of the synovium in rheumatoid arthritis. B cells
por: Mauri, Claudia, et al.
Publicado: (2007)

Cost Effectiveness of TNF-α Inhibitors in Rheumatoid Arthritis
por: Said, Cynthia, et al.
Publicado: (2013)

TNF-α and TNF-β Gene Polymorphism in Saudi Rheumatoid Arthritis Patients
por: Al-Rayes, Hannan, et al.
Publicado: (2011)

Anti-TNF-α effects on anemia in rheumatoid and psoriatic arthritis
por: Corrado, Addolorata, et al.
Publicado: (2017)

Metabolic Effects of Anti-TNF-α Treatment in Rheumatoid Arthritis
por: Macáková, Kristína, et al.
Publicado: (2023)

Regulatory T cells as a biomarker for response to adalimumab in rheumatoid arthritis
por: Nguyen, Dao X., et al.
Publicado: (2018)

Adalimumab regulates intracellular TNFα production in patients with rheumatoid arthritis
por: Zamora-Atenza, Carlos, et al.
Publicado: (2014)

Structural Biology of the TNFα Antagonists Used in the Treatment of Rheumatoid Arthritis
por: Lim, Heejin, et al.
Publicado: (2018)

Aggrecan Turnover in Women with Rheumatoid Arthritis Treated with TNF-α Inhibitors
por: Szeremeta, Anna, et al.
Publicado: (2020)

The Effect of TNF-α on CHD and the Relationship between TNF-α Antagonist and CHD in Rheumatoid Arthritis: A Systematic Review
por: Qian, Yezhou, et al.
Publicado: (2022)

TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts
por: Connor, Alison M, et al.
Publicado: (2012)

Salivary TNFα levels in groups of subjects with rheumatoid arthritis and chronic periodontitis
por: Gamel, Ehsan B., et al.
Publicado: (2017)

The Cytokine Network in Rheumatoid Arthritis: Definition of TNFα as a Therapeutic Target
por: Feldmann, Marc
Publicado: (1996)

Tumor Necrosis Factor (TNF) Bioactivity at the Site of an Acute Cell-Mediated Immune Response Is Preserved in Rheumatoid Arthritis Patients Responding to Anti-TNF Therapy
por: Byng-Maddick, Rachel, et al.
Publicado: (2017)

In vitro response pattern of monocytes after tmTNF reverse signaling predicts response to anti-TNF therapy in rheumatoid arthritis
por: Meusch, Undine, et al.
Publicado: (2015)

Exploring the Inflammatory Metabolomic Profile to Predict Response to TNF-α Inhibitors in Rheumatoid Arthritis
por: Cuppen, Bart V. J., et al.
Publicado: (2016)

No effect of anti-TNF-α treatment on serum IL-17 in patients with rheumatoid arthritis
por: Sikorska, Dorota, et al.
Publicado: (2018)

TNFα expressed on the surface of microparticles modulates endothelial cell fate in rheumatoid arthritis
por: Barbati, Cristiana, et al.
Publicado: (2018)

ADAM17 Genetic Variants and the Response of TNF-α Inhibitor in Rheumatoid Arthritis Patients
por: Kim, Hyun Jeong, et al.
Publicado: (2020)

Bone and TNF in rheumatoid arthritis: clinical implications
por: Manara, Maria, et al.
Publicado: (2015)

Synovial fibroblast hyperplasia correlates with rheumatoid arthritis duration and activity and is partially reversed by anti-TNF therapy
por: Izquierdo, E, et al.
Publicado: (2010)

Rituximab is more effective than second anti-TNF therapy in rheumatoid arthritis patients and previous TNFα blocker failure
por: Kekow, Joern, et al.
Publicado: (2012)

Polymorphism at the position -308 of TNF-α gene influences outcome of infliximab therapy in rheumatoid arthritis
por: Mugnier, B, et al.
Publicado: (2004)

Serum Levels of IL-6 and TNF-α May Correlate with Activity and Severity of Rheumatoid Arthritis
por: Wei, Shi-Tong, et al.
Publicado: (2015)

Mortality in rheumatoid arthritis: the impact of disease activity, treatment with glucocorticoids, TNFα inhibitors and rituximab
por: Listing, Joachim, et al.
Publicado: (2015)

The role of aberrant expression of T cell miRNAs affected by TNF-α in the immunopathogenesis of rheumatoid arthritis
por: Lai, Ning-Sheng, et al.
Publicado: (2017)

Serum adiponectin as a predictor of laboratory response to anti-TNF-α therapy in rheumatoid arthritis
por: Sikorska, Dorota, et al.
Publicado: (2018)

Restored and Enhanced Memory T Cell Immunity in Rheumatoid Arthritis After TNFα Blocker Treatment
por: Khanniche, Asma, et al.
Publicado: (2019)

The recombinant anti-TNF-α fusion protein ameliorates rheumatoid arthritis by the protective role of autophagy
por: Chen, Xiaole, et al.
Publicado: (2020)

Serum Neuropeptide Y Levels Are Associated with TNF-α Levels and Disease Activity in Rheumatoid Arthritis
por: Ramirez-Villafaña, Melissa, et al.
Publicado: (2020)

Bone Metabolism and RANKL/OPG Ratio in Rheumatoid Arthritis Women Treated with TNF-α Inhibitors
por: Jura-Półtorak, Agnieszka, et al.
Publicado: (2021)

Biological Anti-TNF-α Therapy and Markers of Oxidative and Carbonyl Stress in Patients with Rheumatoid Arthritis
por: Šteňová, Emőke, et al.
Publicado: (2021)

Reprogrammed siTNFα/neutrophil cytopharmaceuticals targeting inflamed joints for rheumatoid arthritis therapy
por: Chen, Yijun, et al.
Publicado: (2023)

Regulatory T cells in rheumatoid arthritis
por: Leipe, Jan, et al.
Publicado: (2005)

The Effect of TNF and Non-TNF-Targeted Biologics on Body Composition in Rheumatoid Arthritis
por: Vial, Gaelle, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dmkikaq72ck7k95bal4jcclcd7