Cargando…

Loss of Synchronized Retinal Phagocytosis and Age-related Blindness in Mice Lacking αvβ5 Integrin

Daily phagocytosis by the retinal pigment epithelium (RPE) of spent photoreceptor outer segment fragments is critical for vision. In the retina, early morning circadian photoreceptor rod shedding precedes synchronized uptake of shed photoreceptor particles by RPE cells. In vitro, RPE cells use the i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nandrot, Emeline F., Kim, Yoonhee, Brodie, Scott E., Huang, Xiaozhu, Sheppard, Dean, Finnemann, Silvia C.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211990/ https://www.ncbi.nlm.nih.gov/pubmed/15596525 http://dx.doi.org/10.1084/jem.20041447

Ejemplares similares

Lack of the antioxidant enzyme methionine sulfoxide reductase A in mice impairs RPE phagocytosis and causes photoreceptor cone dysfunction
por: Mazzoni, Francesca, et al.
Publicado: (2021)

Differential Roles of CD36 and αvβ5 Integrin in Photoreceptor Phagocytosis by the Retinal Pigment Epithelium
por: Finnemann, Silvia C., et al.
Publicado: (2001)

The Signalling Role of the αvβ5-Integrin Can Impact the Efficacy of AAV in Retinal Gene Therapy
por: Cronin, Therese, et al.
Publicado: (2012)

Essential diurnal Rac1 activation during retinal phagocytosis requires αvβ5 integrin but not tyrosine kinases focal adhesion kinase or Mer tyrosine kinase
por: Mao, Yingyu, et al.
Publicado: (2012)

Macrophage and Retinal Pigment Epithelium Phagocytosis: Apoptotic Cells and Photoreceptors Compete for αvβ3 and αvβ5 Integrins, and Protein Kinase C Regulates αvβ5 Binding and Cytoskeletal Linkage
por: Finnemann, Silvia C., et al.
Publicado: (1999)

Microglia Inhibition Delays Retinal Degeneration Due to MerTK Phagocytosis Receptor Deficiency
por: Lew, Deborah S., et al.
Publicado: (2020)

Pleiotropic Roles of Scavenger Receptors in Circadian Retinal Phagocytosis: A New Function for Lysosomal SR-B2/LIMP-2 at the RPE Cell Surface
por: Rieu, Quentin, et al.
Publicado: (2022)

Galectin-3 Promotes Müller Glia Clearance Phagocytosis via MERTK and Reduces Harmful Müller Glia Activation in Inherited and Induced Retinal Degeneration
por: Lew, Deborah S., et al.
Publicado: (2022)

Probing Photoreceptor Outer Segment Phagocytosis by the RPE In Vivo: Models and Methodologies
por: Vargas, Jade A., et al.
Publicado: (2022)

Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK
por: Mao, Yingyu, et al.
Publicado: (2021)

A novel quantification method for retinal pigment epithelium phagocytosis using a very-long-chain polyunsaturated fatty acids-based strategy
por: Gao, Fangyuan, et al.
Publicado: (2023)

Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling
por: Eliceiri, Brian P., et al.
Publicado: (2002)

The Activation and Regulation of β2 Integrins in Phagocytes and Phagocytosis
por: Sun, Hao, et al.
Publicado: (2021)

Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration
por: Greenhalgh, Stephen N., et al.
Publicado: (2019)

The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis
por: Flannagan, Ronald S., et al.
Publicado: (2014)

Signal Regulatory Protein α Negatively Regulates β(2) Integrin-Mediated Monocyte Adhesion, Transendothelial Migration and Phagocytosis
por: Liu, Dan-Qing, et al.
Publicado: (2008)

Reduced fibulin-2 contributes to loss of basement membrane integrity and skin blistering in mice lacking integrin α3β1 in the epidermis
por: Longmate, Whitney M., et al.
Publicado: (2014)

Regulator of G-Protein Signalling-14 (RGS14) Regulates the Activation of αMβ2 Integrin during Phagocytosis
por: Lim, Jenson, et al.
Publicado: (2013)

αVβ8 integrin targeting to prevent posterior capsular opacification
por: Shihan, Mahbubul H., et al.
Publicado: (2021)

Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease
por: Katsumoto, Tamiko R., et al.
Publicado: (2011)

Integrin-α9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis
por: Bazigou, Eleni, et al.
Publicado: (2009)

JNK pathway activation is able to synchronize neuronal death and glial phagocytosis in Drosophila
por: Shklover, J, et al.
Publicado: (2015)

Spermidine/spermine N (1)-acetyltransferase specifically binds to the integrin α9 subunit cytoplasmic domain and enhances cell migration
por: Chen, Chun, et al.
Publicado: (2004)

Phagocytosis by the Retinal Pigment Epithelium: Recognition, Resolution, Recycling
por: Kwon, Whijin, et al.
Publicado: (2020)

The Integrin α9β1 Mediates Adhesion to Activated Endothelial Cells and Transendothelial Neutrophil Migration through Interaction with Vascular Cell Adhesion Molecule-1
por: Taooka, Yasuyuki, et al.
Publicado: (1999)

Normal Fertilization Occurs with Eggs Lacking the Integrin α6β1 and Is Cd9-Dependent
por: Miller, Brent J., et al.
Publicado: (2000)

Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration
por: Zhao, Lian, et al.
Publicado: (2015)

Lack of α8 integrin leads to morphological changes in renal mesangial cells, but not in vascular smooth muscle cells
por: Marek, Ines, et al.
Publicado: (2010)

Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis
por: Nishimichi, Norihisa, et al.
Publicado: (2021)

Preclinical safety studies of human embryonic stem cell‐derived retinal pigment epithelial cells for the treatment of age‐related macular degeneration
por: Petrus‐Reurer, Sandra, et al.
Publicado: (2020)

Modeling PRPF31 retinitis pigmentosa using retinal pigment epithelium and organoids combined with gene augmentation rescue
por: Rodrigues, Amélie, et al.
Publicado: (2022)

A novel member of the integrin receptor family mediates Arg-Gly-Asp- stimulated neutrophil phagocytosis
Publicado: (1989)

A Small GTPase, RhoA, Inhibits Bacterial Infection Through Integrin Mediated Phagocytosis in Invertebrates
por: Xu, Ji-Dong, et al.
Publicado: (2018)

Rat retinal pigment epithelial cells show specificity of phagocytosis in vitro
Publicado: (1986)

ABCF1 extrinsically regulates retinal pigment epithelial cell phagocytosis
por: Guo, Feiye, et al.
Publicado: (2015)

Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation
por: Touhami, Sara, et al.
Publicado: (2018)

Ezrin Promotes Morphogenesis of Apical Microvilli and Basal Infoldings in Retinal Pigment Epithelium
por: Bonilha, Vera Lúcia, et al.
Publicado: (1999)

Nystagmus in patients with congenital stationary night blindness (CSNB) originates from synchronously firing retinal ganglion cells
por: Winkelman, Beerend H. J., et al.
Publicado: (2019)

Integrin beta 3 cytoplasmic tail is necessary and sufficient for regulation of alpha 5 beta 1 phagocytosis by alpha v beta 3 and integrin-associated protein
Publicado: (1995)

αvβ5 Integrin/FAK/PGC-1α Pathway Confers Protective Effects on Retinal Pigment Epithelium
por: Roggia, Murilo F., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_7ui3j9k4edrda07f2pfkmjqkd1