Age-related Defects in CD4 T Cell Cognate Helper Function Lead to Reductions in Humoral Responses

With increasing age, the ability to produce protective antibodies in response to immunization declines, leading to a reduced efficacy of vaccination in the elderly. To examine the effect of age on the cognate function of CD4 T cells, we have used a novel adoptive transfer model that allows us to com...

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Detalles Bibliográficos
Autores principales: Eaton, Sheri M., Burns, Eve M., Kusser, Kimberly, Randall, Troy D., Haynes, Laura
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211991/
https://www.ncbi.nlm.nih.gov/pubmed/15611289
http://dx.doi.org/10.1084/jem.20041395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211991/
https://www.ncbi.nlm.nih.gov/pubmed/15611289
http://dx.doi.org/10.1084/jem.20041395

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