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Age-related Defects in CD4 T Cell Cognate Helper Function Lead to Reductions in Humoral Responses
With increasing age, the ability to produce protective antibodies in response to immunization declines, leading to a reduced efficacy of vaccination in the elderly. To examine the effect of age on the cognate function of CD4 T cells, we have used a novel adoptive transfer model that allows us to com...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211991/ https://www.ncbi.nlm.nih.gov/pubmed/15611289 http://dx.doi.org/10.1084/jem.20041395 |