Finding a Place for Tumor-specific T Cells in Targeted Cancer Therapy

A goal in cancer therapeutics is to develop targeted modalities that distinguish malignant from normal cells. T cells can discriminate diseased cells based on subtle alterations in peptides displayed in association with MHC molecules at the cell surface. Recent success using the adoptive transfer of...

Descripción completa

Detalles Bibliográficos
Autor principal: Riddell, Stanley R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212006/
https://www.ncbi.nlm.nih.gov/pubmed/15611285
http://dx.doi.org/10.1084/jem.20042004
_version_ 1782148602234142720
author Riddell, Stanley R.
author_facet Riddell, Stanley R.
author_sort Riddell, Stanley R.
collection PubMed
description A goal in cancer therapeutics is to develop targeted modalities that distinguish malignant from normal cells. T cells can discriminate diseased cells based on subtle alterations in peptides displayed in association with MHC molecules at the cell surface. Recent success using the adoptive transfer of tumor-specific T cells has fueled optimism that this approach may find a place as a targeted therapy for some human cancers.
format Text
id pubmed-2212006
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-22120062008-03-11 Finding a Place for Tumor-specific T Cells in Targeted Cancer Therapy Riddell, Stanley R. J Exp Med Commentary A goal in cancer therapeutics is to develop targeted modalities that distinguish malignant from normal cells. T cells can discriminate diseased cells based on subtle alterations in peptides displayed in association with MHC molecules at the cell surface. Recent success using the adoptive transfer of tumor-specific T cells has fueled optimism that this approach may find a place as a targeted therapy for some human cancers. The Rockefeller University Press 2004-12-20 /pmc/articles/PMC2212006/ /pubmed/15611285 http://dx.doi.org/10.1084/jem.20042004 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Riddell, Stanley R.
Finding a Place for Tumor-specific T Cells in Targeted Cancer Therapy
title Finding a Place for Tumor-specific T Cells in Targeted Cancer Therapy
title_full Finding a Place for Tumor-specific T Cells in Targeted Cancer Therapy
title_fullStr Finding a Place for Tumor-specific T Cells in Targeted Cancer Therapy
title_full_unstemmed Finding a Place for Tumor-specific T Cells in Targeted Cancer Therapy
title_short Finding a Place for Tumor-specific T Cells in Targeted Cancer Therapy
title_sort finding a place for tumor-specific t cells in targeted cancer therapy
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212006/
https://www.ncbi.nlm.nih.gov/pubmed/15611285
http://dx.doi.org/10.1084/jem.20042004
work_keys_str_mv AT riddellstanleyr findingaplacefortumorspecifictcellsintargetedcancertherapy

Ejemplares similares