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Protein Kinase C θ Is Critical for the Development of In Vivo T Helper (Th)2 Cell But Not Th1 Cell Responses

The serine/threonine-specific protein kinase C (PKC)-θ is predominantly expressed in T cells and localizes to the center of the immunological synapse upon T cell receptor (TCR) and CD28 signaling. T cells deficient in PKC-θ exhibit reduced interleukin (IL)-2 production and proliferative responses in...

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Detalles Bibliográficos
Autores principales:	Marsland, Benjamin J., Soos, Timothy J., Späth, Gerald, Littman, Dan R., Kopf, Manfred
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212016/ https://www.ncbi.nlm.nih.gov/pubmed/15263025 http://dx.doi.org/10.1084/jem.20032229

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