No audible wheezing: nuggets and conundrums from mouse asthma models

Mouse models of T helper type 2 (Th2) cell–biased pulmonary inflammation have elucidated mechanisms of sensitization, cell traffic, and induced airway hyperresponsiveness (AHR). Nonetheless, most mice lack intrinsic AHR, a central property of human asthma, and disparities persist regarding the contr...

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Detalles Bibliográficos
Autores principales: Boyce, Joshua A., Austen, K. Frank
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212041/
https://www.ncbi.nlm.nih.gov/pubmed/15967817
http://dx.doi.org/10.1084/jem.20050584
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author Boyce, Joshua A.
Austen, K. Frank
author_facet Boyce, Joshua A.
Austen, K. Frank
author_sort Boyce, Joshua A.
collection PubMed
description Mouse models of T helper type 2 (Th2) cell–biased pulmonary inflammation have elucidated mechanisms of sensitization, cell traffic, and induced airway hyperresponsiveness (AHR). Nonetheless, most mice lack intrinsic AHR, a central property of human asthma, and disparities persist regarding the contributions of eosinophils and mast cells and the sensitivity to induced AHR in the commonly used mouse strains. We suggest that these discordances, reflecting methodological and genetic differences, may be informative for understanding heterogeneity of human asthma.
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spelling pubmed-22120412008-03-11 No audible wheezing: nuggets and conundrums from mouse asthma models Boyce, Joshua A. Austen, K. Frank J Exp Med Commentary Mouse models of T helper type 2 (Th2) cell–biased pulmonary inflammation have elucidated mechanisms of sensitization, cell traffic, and induced airway hyperresponsiveness (AHR). Nonetheless, most mice lack intrinsic AHR, a central property of human asthma, and disparities persist regarding the contributions of eosinophils and mast cells and the sensitivity to induced AHR in the commonly used mouse strains. We suggest that these discordances, reflecting methodological and genetic differences, may be informative for understanding heterogeneity of human asthma. The Rockefeller University Press 2005-06-20 /pmc/articles/PMC2212041/ /pubmed/15967817 http://dx.doi.org/10.1084/jem.20050584 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Boyce, Joshua A.
Austen, K. Frank
No audible wheezing: nuggets and conundrums from mouse asthma models
title No audible wheezing: nuggets and conundrums from mouse asthma models
title_full No audible wheezing: nuggets and conundrums from mouse asthma models
title_fullStr No audible wheezing: nuggets and conundrums from mouse asthma models
title_full_unstemmed No audible wheezing: nuggets and conundrums from mouse asthma models
title_short No audible wheezing: nuggets and conundrums from mouse asthma models
title_sort no audible wheezing: nuggets and conundrums from mouse asthma models
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212041/
https://www.ncbi.nlm.nih.gov/pubmed/15967817
http://dx.doi.org/10.1084/jem.20050584
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