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EXPERIMENTS ON THE CAUSE OF THE RABBIT CARCINOMAS DERIVED FROM VIRUS-INDUCED PAPILLOMAS : I. PROPAGATION OF SEVERAL OF THE CANCERS IN SUCKLINGS, WITH ETIOLOGICAL TESTS

Three out of four carcinomas arising from rims-induced, rabbit papillomas have grown well after transplantation to sucklings. Two were propagated serially, and it seems likely that all could have been maintained indefinitely had litters been available of newborn animals of the sort in which they aro...

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Autores principales: Smith, William E., Kidd, John G., Rous, Peyton
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1952
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212077/
https://www.ncbi.nlm.nih.gov/pubmed/14927795
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author Smith, William E.
Kidd, John G.
Rous, Peyton
author_facet Smith, William E.
Kidd, John G.
Rous, Peyton
author_sort Smith, William E.
collection PubMed
description Three out of four carcinomas arising from rims-induced, rabbit papillomas have grown well after transplantation to sucklings. Two were propagated serially, and it seems likely that all could have been maintained indefinitely had litters been available of newborn animals of the sort in which they arose. These successes are the more worthy of note because of the well-nigh uniform failure of similar growths on transfer to adults. The tumors enlarged with great rapidity in the sucklings, were extraordinarily destructive, and two of them metastaslzed within a few weeks. Many efforts were made to extract causative agents from the three carcinomas, on the assumption that these might be due to variants of the Shope virus. Highly favorable conditions for the demonstration of this latter were provided in the tests; yet their outcome was wholly negative although all of the cancers derived from papillomas caused by "recoverable" strains of virus, and although one of them appeared to be consequent upon only the slightest of alterations toward malignancy on the part of the papilloma from which it came. Extracts of another of the cancers, an anaplastic, squamous-cell carcinoma devoid of any morphological sign of the influence of the Shope virus, yielded typical virus papillomas on several occasions. The wholly negative results with the third cancer must be considered in the light of the fact that the "recoverable" strain of virus causing the papilloma from which it originated could no longer be recovered from such growths on collateral test.
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spelling pubmed-22120772008-04-17 EXPERIMENTS ON THE CAUSE OF THE RABBIT CARCINOMAS DERIVED FROM VIRUS-INDUCED PAPILLOMAS : I. PROPAGATION OF SEVERAL OF THE CANCERS IN SUCKLINGS, WITH ETIOLOGICAL TESTS Smith, William E. Kidd, John G. Rous, Peyton J Exp Med Article Three out of four carcinomas arising from rims-induced, rabbit papillomas have grown well after transplantation to sucklings. Two were propagated serially, and it seems likely that all could have been maintained indefinitely had litters been available of newborn animals of the sort in which they arose. These successes are the more worthy of note because of the well-nigh uniform failure of similar growths on transfer to adults. The tumors enlarged with great rapidity in the sucklings, were extraordinarily destructive, and two of them metastaslzed within a few weeks. Many efforts were made to extract causative agents from the three carcinomas, on the assumption that these might be due to variants of the Shope virus. Highly favorable conditions for the demonstration of this latter were provided in the tests; yet their outcome was wholly negative although all of the cancers derived from papillomas caused by "recoverable" strains of virus, and although one of them appeared to be consequent upon only the slightest of alterations toward malignancy on the part of the papilloma from which it came. Extracts of another of the cancers, an anaplastic, squamous-cell carcinoma devoid of any morphological sign of the influence of the Shope virus, yielded typical virus papillomas on several occasions. The wholly negative results with the third cancer must be considered in the light of the fact that the "recoverable" strain of virus causing the papilloma from which it originated could no longer be recovered from such growths on collateral test. The Rockefeller University Press 1952-02-29 /pmc/articles/PMC2212077/ /pubmed/14927795 Text en Copyright © Copyright, 1952, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Smith, William E.
Kidd, John G.
Rous, Peyton
EXPERIMENTS ON THE CAUSE OF THE RABBIT CARCINOMAS DERIVED FROM VIRUS-INDUCED PAPILLOMAS : I. PROPAGATION OF SEVERAL OF THE CANCERS IN SUCKLINGS, WITH ETIOLOGICAL TESTS
title EXPERIMENTS ON THE CAUSE OF THE RABBIT CARCINOMAS DERIVED FROM VIRUS-INDUCED PAPILLOMAS : I. PROPAGATION OF SEVERAL OF THE CANCERS IN SUCKLINGS, WITH ETIOLOGICAL TESTS
title_full EXPERIMENTS ON THE CAUSE OF THE RABBIT CARCINOMAS DERIVED FROM VIRUS-INDUCED PAPILLOMAS : I. PROPAGATION OF SEVERAL OF THE CANCERS IN SUCKLINGS, WITH ETIOLOGICAL TESTS
title_fullStr EXPERIMENTS ON THE CAUSE OF THE RABBIT CARCINOMAS DERIVED FROM VIRUS-INDUCED PAPILLOMAS : I. PROPAGATION OF SEVERAL OF THE CANCERS IN SUCKLINGS, WITH ETIOLOGICAL TESTS
title_full_unstemmed EXPERIMENTS ON THE CAUSE OF THE RABBIT CARCINOMAS DERIVED FROM VIRUS-INDUCED PAPILLOMAS : I. PROPAGATION OF SEVERAL OF THE CANCERS IN SUCKLINGS, WITH ETIOLOGICAL TESTS
title_short EXPERIMENTS ON THE CAUSE OF THE RABBIT CARCINOMAS DERIVED FROM VIRUS-INDUCED PAPILLOMAS : I. PROPAGATION OF SEVERAL OF THE CANCERS IN SUCKLINGS, WITH ETIOLOGICAL TESTS
title_sort experiments on the cause of the rabbit carcinomas derived from virus-induced papillomas : i. propagation of several of the cancers in sucklings, with etiological tests
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212077/
https://www.ncbi.nlm.nih.gov/pubmed/14927795
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