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RADIOAUTOGRAPHIC STUDIES OF SULFATE-SULFUR (S(35)) METABOLISM IN THE ARTICULAR CARTILAGE AND BONE OF SUCKLING RATS

Fifteen minutes after intraperitoneal injection of sulfur-35 as sodium sulfate to 7-day-old rats the concentration of the isotope was highest in the cartilage at the epiphyseal-diaphyseal junction of long bones but was demonstrable throughout the entire epiphysis. Up to the 24th hour the pattern of...

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Autor principal: Dziewiatkowski, Dominic D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1952
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212079/
https://www.ncbi.nlm.nih.gov/pubmed/14927801
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author Dziewiatkowski, Dominic D.
author_facet Dziewiatkowski, Dominic D.
author_sort Dziewiatkowski, Dominic D.
collection PubMed
description Fifteen minutes after intraperitoneal injection of sulfur-35 as sodium sulfate to 7-day-old rats the concentration of the isotope was highest in the cartilage at the epiphyseal-diaphyseal junction of long bones but was demonstrable throughout the entire epiphysis. Up to the 24th hour the pattern of deposition did not change as the concentration continued to increase. As centers of secondary ossification developed, there occurred in them an increased concentration of some form of sulfur, insoluble as the barium salt. This sulfur was probably derived from the cartilage which the center of secondary ossification replaced. Up to about the 30th minute after injection the sulfur-35 was deposited transitorily in a high concentration in discrete loci of the bone marrow. Excluding this transitory deposition, the highest concentration of the radioisotope in the bone marrow was seen in the specimens removed 24 hours after administration. In the bone shaft the sulfur-35, in a form which was insoluble in an alkaline solution of barium ions, was deposited diffusely up to the 24th hour after its administration. Thereafter, the radioisotope decreased in concentration in the middle portion of the bone shaft. However, the concentration of a similarly characterized sulfur-35-bearing component in the ends of the diaphysis continued to increase up to at least the 96th hour after injection.
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spelling pubmed-22120792008-04-17 RADIOAUTOGRAPHIC STUDIES OF SULFATE-SULFUR (S(35)) METABOLISM IN THE ARTICULAR CARTILAGE AND BONE OF SUCKLING RATS Dziewiatkowski, Dominic D. J Exp Med Article Fifteen minutes after intraperitoneal injection of sulfur-35 as sodium sulfate to 7-day-old rats the concentration of the isotope was highest in the cartilage at the epiphyseal-diaphyseal junction of long bones but was demonstrable throughout the entire epiphysis. Up to the 24th hour the pattern of deposition did not change as the concentration continued to increase. As centers of secondary ossification developed, there occurred in them an increased concentration of some form of sulfur, insoluble as the barium salt. This sulfur was probably derived from the cartilage which the center of secondary ossification replaced. Up to about the 30th minute after injection the sulfur-35 was deposited transitorily in a high concentration in discrete loci of the bone marrow. Excluding this transitory deposition, the highest concentration of the radioisotope in the bone marrow was seen in the specimens removed 24 hours after administration. In the bone shaft the sulfur-35, in a form which was insoluble in an alkaline solution of barium ions, was deposited diffusely up to the 24th hour after its administration. Thereafter, the radioisotope decreased in concentration in the middle portion of the bone shaft. However, the concentration of a similarly characterized sulfur-35-bearing component in the ends of the diaphysis continued to increase up to at least the 96th hour after injection. The Rockefeller University Press 1952-05-01 /pmc/articles/PMC2212079/ /pubmed/14927801 Text en Copyright © Copyright, 1952, by The Rockefeller Institute for Medical Research New York This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Dziewiatkowski, Dominic D.
RADIOAUTOGRAPHIC STUDIES OF SULFATE-SULFUR (S(35)) METABOLISM IN THE ARTICULAR CARTILAGE AND BONE OF SUCKLING RATS
title RADIOAUTOGRAPHIC STUDIES OF SULFATE-SULFUR (S(35)) METABOLISM IN THE ARTICULAR CARTILAGE AND BONE OF SUCKLING RATS
title_full RADIOAUTOGRAPHIC STUDIES OF SULFATE-SULFUR (S(35)) METABOLISM IN THE ARTICULAR CARTILAGE AND BONE OF SUCKLING RATS
title_fullStr RADIOAUTOGRAPHIC STUDIES OF SULFATE-SULFUR (S(35)) METABOLISM IN THE ARTICULAR CARTILAGE AND BONE OF SUCKLING RATS
title_full_unstemmed RADIOAUTOGRAPHIC STUDIES OF SULFATE-SULFUR (S(35)) METABOLISM IN THE ARTICULAR CARTILAGE AND BONE OF SUCKLING RATS
title_short RADIOAUTOGRAPHIC STUDIES OF SULFATE-SULFUR (S(35)) METABOLISM IN THE ARTICULAR CARTILAGE AND BONE OF SUCKLING RATS
title_sort radioautographic studies of sulfate-sulfur (s(35)) metabolism in the articular cartilage and bone of suckling rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212079/
https://www.ncbi.nlm.nih.gov/pubmed/14927801
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