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Nucleoside Analogue Reverse Transcriptase Inhibitors Differentially Inhibit Human LINE-1 Retrotransposition

BACKGROUND: Intact LINE-1 elements are the only retrotransposons encoded by the human genome known to be capable of autonomous replication. Numerous cases of genetic disease have been traced to gene disruptions caused by LINE-1 retrotransposition events in germ-line cells. In addition, genomic insta...

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Detalles Bibliográficos
Autores principales:	Jones, R. Brad, Garrison, Keith E., Wong, Jessica C., Duan, Erick H., Nixon, Douglas F., Ostrowski, Mario A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212136/ https://www.ncbi.nlm.nih.gov/pubmed/18253495 http://dx.doi.org/10.1371/journal.pone.0001547

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