Subsets of Transgenic T Cells That Recognize CD1 Induce or Prevent Murine Lupus: Role of Cytokines

T cells with T cell receptor (TCR) transgenes that recognized CD1 on syngeneic B cells stimulated B cells to secrete immunoglobulins in vitro. The CD4(+), CD8(+), or CD4(−)CD8(−) T cells from the spleen of the TCR transgenic BALB/c donors induced lupus with anti–double stranded DNA antibodies, prote...

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Autores principales: Zeng, Defu, Dick, Michael, Cheng, Lirong, Amano, Masahiko, Dejbakhsh-Jones, Sussan, Huie, Philip, Sibley, Richard, Strober, Samuel
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212154/
https://www.ncbi.nlm.nih.gov/pubmed/9463403
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author Zeng, Defu
Dick, Michael
Cheng, Lirong
Amano, Masahiko
Dejbakhsh-Jones, Sussan
Huie, Philip
Sibley, Richard
Strober, Samuel
author_facet Zeng, Defu
Dick, Michael
Cheng, Lirong
Amano, Masahiko
Dejbakhsh-Jones, Sussan
Huie, Philip
Sibley, Richard
Strober, Samuel
author_sort Zeng, Defu
collection PubMed
description T cells with T cell receptor (TCR) transgenes that recognized CD1 on syngeneic B cells stimulated B cells to secrete immunoglobulins in vitro. The CD4(+), CD8(+), or CD4(−)CD8(−) T cells from the spleen of the TCR transgenic BALB/c donors induced lupus with anti–double stranded DNA antibodies, proteinuria, and immune complex glomerulonephritis in irradiated BALB/c nude mice reconstituted with nude bone marrow. Injection of purified CD4(−)CD8(−) T cells from the marrow of transgenic donors prevented the induction of lupus by the transgenic T cells. Transgenic T cells that induced lupus secreted large amounts of interferon (IFN)-γ and little interleukin (IL)-4, and those that prevented lupus secreted large amounts of IL-4 and little IFN-γ or IL-10.
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spelling pubmed-22121542008-04-16 Subsets of Transgenic T Cells That Recognize CD1 Induce or Prevent Murine Lupus: Role of Cytokines Zeng, Defu Dick, Michael Cheng, Lirong Amano, Masahiko Dejbakhsh-Jones, Sussan Huie, Philip Sibley, Richard Strober, Samuel J Exp Med Article T cells with T cell receptor (TCR) transgenes that recognized CD1 on syngeneic B cells stimulated B cells to secrete immunoglobulins in vitro. The CD4(+), CD8(+), or CD4(−)CD8(−) T cells from the spleen of the TCR transgenic BALB/c donors induced lupus with anti–double stranded DNA antibodies, proteinuria, and immune complex glomerulonephritis in irradiated BALB/c nude mice reconstituted with nude bone marrow. Injection of purified CD4(−)CD8(−) T cells from the marrow of transgenic donors prevented the induction of lupus by the transgenic T cells. Transgenic T cells that induced lupus secreted large amounts of interferon (IFN)-γ and little interleukin (IL)-4, and those that prevented lupus secreted large amounts of IL-4 and little IFN-γ or IL-10. The Rockefeller University Press 1998-02-16 /pmc/articles/PMC2212154/ /pubmed/9463403 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Zeng, Defu
Dick, Michael
Cheng, Lirong
Amano, Masahiko
Dejbakhsh-Jones, Sussan
Huie, Philip
Sibley, Richard
Strober, Samuel
Subsets of Transgenic T Cells That Recognize CD1 Induce or Prevent Murine Lupus: Role of Cytokines
title Subsets of Transgenic T Cells That Recognize CD1 Induce or Prevent Murine Lupus: Role of Cytokines
title_full Subsets of Transgenic T Cells That Recognize CD1 Induce or Prevent Murine Lupus: Role of Cytokines
title_fullStr Subsets of Transgenic T Cells That Recognize CD1 Induce or Prevent Murine Lupus: Role of Cytokines
title_full_unstemmed Subsets of Transgenic T Cells That Recognize CD1 Induce or Prevent Murine Lupus: Role of Cytokines
title_short Subsets of Transgenic T Cells That Recognize CD1 Induce or Prevent Murine Lupus: Role of Cytokines
title_sort subsets of transgenic t cells that recognize cd1 induce or prevent murine lupus: role of cytokines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212154/
https://www.ncbi.nlm.nih.gov/pubmed/9463403
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