Disturbed CD4(+) T Cell Homeostasis and In Vitro HIV-1 Susceptibility in Transgenic Mice Expressing T Cell Line–tropic HIV-1 Receptors

T cell line–tropic (T-tropic) HIV type 1 strains enter cells by interacting with the cell-surface molecules CD4 and CXCR4. We have generated transgenic mice predominantly expressing human CD4 and CXCR4 on their CD4-positive T lymphocytes (CD4(+) T cells). Their primary thymocytes are susceptible to...

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Detalles Bibliográficos
Autores principales: Sawada, Shinichiro, Gowrishankar, Kavitha, Kitamura, Rui, Suzuki, Misao, Suzuki, Gen, Tahara, Satoko, Koito, Atsushi
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212262/
https://www.ncbi.nlm.nih.gov/pubmed/9565636

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