Challenging Cytokine Redundancy: Inflammatory Cell Movement and Clinical Course of Experimental Autoimmune Encephalomyelitis Are Normal in Lymphotoxin-deficient, but Not Tumor Necrosis Factor–deficient, Mice

Lymphotoxin (LT) is widely regarded as a proinflammatory cytokine with activities equivalent to tumor necrosis factor (TNF). The contribution of LT to experimental autoimmune encephalomyelitis (EAE) was examined using TNF/LTα(−/−) mice, TNF(−/−) mice, and a new LTα(−/−) line described here. All mice...

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Detalles Bibliográficos
Autores principales: Sean Riminton, D., Körner, Heinrich, Strickland, Deborah H., Lemckert, Frances A., Pollard, John D., Sedgwick, Jonathon D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212266/
https://www.ncbi.nlm.nih.gov/pubmed/9565643

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