Inactivation of a Defined Active Site in the Mouse 20S Proteasome Complex Enhances Major Histocompatibility Complex Class I Antigen Presentation of a Murine Cytomegalovirus Protein

Proteasomes generate peptides bound by major histocompatibility complex (MHC) class I molecules. Avoiding proteasome inhibitors, which in most cases do not distinguish between individual active sites within the cell, we used a molecular genetic approach that allowed for the first time the in vivo an...

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Detalles Bibliográficos
Autores principales: Schmidtke, Gunter, Eggers, Maren, Ruppert, Thomas, Groettrup, Marcus, Koszinowski, Ulrich H., Kloetzel, Peter-M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212286/
https://www.ncbi.nlm.nih.gov/pubmed/9584142

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