Cargando…

Protective Immunity Does Not Correlate with the Hierarchy of  Virus-specific Cytotoxic T Cell Responses to Naturally Processed Peptides

Infection of C57BL/6 mice with lymphocytic choriomeningitis virus (LCMV) stimulates major histocompatibility complex class I–restricted cytotoxic T cells (CTLs), which normally resolve the infection. Three peptide epitopes derived from LCMV have been shown to bind the mouse class I molecule H-2 D(b)...

Descripción completa

Detalles Bibliográficos
Autores principales: Gallimore, Awen, Dumrese, Tilman, Hengartner, Hans, Zinkernagel, Rolf M., Rammensee, Hans-Georg
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212291/
https://www.ncbi.nlm.nih.gov/pubmed/9584143
_version_ 1782148664492294144
author Gallimore, Awen
Dumrese, Tilman
Hengartner, Hans
Zinkernagel, Rolf M.
Rammensee, Hans-Georg
author_facet Gallimore, Awen
Dumrese, Tilman
Hengartner, Hans
Zinkernagel, Rolf M.
Rammensee, Hans-Georg
author_sort Gallimore, Awen
collection PubMed
description Infection of C57BL/6 mice with lymphocytic choriomeningitis virus (LCMV) stimulates major histocompatibility complex class I–restricted cytotoxic T cells (CTLs), which normally resolve the infection. Three peptide epitopes derived from LCMV have been shown to bind the mouse class I molecule H-2 D(b) and to stimulate CTL responses in LCMV-infected mice. This report describes the identity and abundance of each CTL epitope after their elution from LCMV-infected cells. Based on this information, peptide abundance was found to correlate with the magnitude of each CTL response generated after infection with LCMV. Subsequent experiments, performed to determine the antiviral capacity of each CTL specificity, indicate that the quantitative hierarchy of CTL activity does not correlate with the ability to protect against LCMV infection. This report, therefore, indicates that immunodominant epitopes should be defined, not only by the strength of the CTL response that they stimulate, but also by the ability of the CTLs to protect against infection.
format Text
id pubmed-2212291
institution National Center for Biotechnology Information
language English
publishDate 1998
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-22122912008-04-16 Protective Immunity Does Not Correlate with the Hierarchy of  Virus-specific Cytotoxic T Cell Responses to Naturally Processed Peptides Gallimore, Awen Dumrese, Tilman Hengartner, Hans Zinkernagel, Rolf M. Rammensee, Hans-Georg J Exp Med Article Infection of C57BL/6 mice with lymphocytic choriomeningitis virus (LCMV) stimulates major histocompatibility complex class I–restricted cytotoxic T cells (CTLs), which normally resolve the infection. Three peptide epitopes derived from LCMV have been shown to bind the mouse class I molecule H-2 D(b) and to stimulate CTL responses in LCMV-infected mice. This report describes the identity and abundance of each CTL epitope after their elution from LCMV-infected cells. Based on this information, peptide abundance was found to correlate with the magnitude of each CTL response generated after infection with LCMV. Subsequent experiments, performed to determine the antiviral capacity of each CTL specificity, indicate that the quantitative hierarchy of CTL activity does not correlate with the ability to protect against LCMV infection. This report, therefore, indicates that immunodominant epitopes should be defined, not only by the strength of the CTL response that they stimulate, but also by the ability of the CTLs to protect against infection. The Rockefeller University Press 1998-05-18 /pmc/articles/PMC2212291/ /pubmed/9584143 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Gallimore, Awen
Dumrese, Tilman
Hengartner, Hans
Zinkernagel, Rolf M.
Rammensee, Hans-Georg
Protective Immunity Does Not Correlate with the Hierarchy of  Virus-specific Cytotoxic T Cell Responses to Naturally Processed Peptides
title Protective Immunity Does Not Correlate with the Hierarchy of  Virus-specific Cytotoxic T Cell Responses to Naturally Processed Peptides
title_full Protective Immunity Does Not Correlate with the Hierarchy of  Virus-specific Cytotoxic T Cell Responses to Naturally Processed Peptides
title_fullStr Protective Immunity Does Not Correlate with the Hierarchy of  Virus-specific Cytotoxic T Cell Responses to Naturally Processed Peptides
title_full_unstemmed Protective Immunity Does Not Correlate with the Hierarchy of  Virus-specific Cytotoxic T Cell Responses to Naturally Processed Peptides
title_short Protective Immunity Does Not Correlate with the Hierarchy of  Virus-specific Cytotoxic T Cell Responses to Naturally Processed Peptides
title_sort protective immunity does not correlate with the hierarchy of  virus-specific cytotoxic t cell responses to naturally processed peptides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212291/
https://www.ncbi.nlm.nih.gov/pubmed/9584143
work_keys_str_mv AT gallimoreawen protectiveimmunitydoesnotcorrelatewiththehierarchyofvirusspecificcytotoxictcellresponsestonaturallyprocessedpeptides
AT dumresetilman protectiveimmunitydoesnotcorrelatewiththehierarchyofvirusspecificcytotoxictcellresponsestonaturallyprocessedpeptides
AT hengartnerhans protectiveimmunitydoesnotcorrelatewiththehierarchyofvirusspecificcytotoxictcellresponsestonaturallyprocessedpeptides
AT zinkernagelrolfm protectiveimmunitydoesnotcorrelatewiththehierarchyofvirusspecificcytotoxictcellresponsestonaturallyprocessedpeptides
AT rammenseehansgeorg protectiveimmunitydoesnotcorrelatewiththehierarchyofvirusspecificcytotoxictcellresponsestonaturallyprocessedpeptides