Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice

To investigate the possible involvement of DNA repair in the process of somatic hypermutation of rearranged immunoglobulin variable (V) region genes, we have analyzed the occurrence, frequency, distribution, and pattern of mutations in rearranged Vλ1 light chain genes from naive and memory B cells i...

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Detalles Bibliográficos
Autores principales: Jacobs, Heinz, Fukita, Yosho, van der Horst, Gijsbertus T.J., de Boer, Jan, Weeda, Geert, Essers, Jeroen, de Wind, Niels, Engelward, Bevin P., Samson, Leona, Verbeek, Sjef, de Murcia, Josiane Ménissier, de Murcia, Gilbert, e Riele, Hein t, Rajewsky, Klaus
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212309/
https://www.ncbi.nlm.nih.gov/pubmed/9607915

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