A Nongenomic Mechanism for Progesterone-mediated Immunosuppression: Inhibition of K(+) Channels, Ca(2+) Signaling, and Gene Expression in T Lymphocytes

The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and reversibly blocks voltage-gated and calcium-activ...

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Detalles Bibliográficos
Autores principales: Ehring, George R., Kerschbaum, Hubert H., Eder, Claudia, Neben, Amber L., Fanger, Christopher M., Khoury, Rosana M., Negulescu, Paul A., Cahalan, Michael D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212508/
https://www.ncbi.nlm.nih.gov/pubmed/9802971

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