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A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity

Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%. Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been confirmed. By studying animal models, reduced capacity of the NADPH-oxidase (NOX) complex, caused by a single...

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Detalles Bibliográficos
Autores principales:	Olsson, Lina M, Lindqvist, Anna-Karin, Källberg, Henrik, Padyukov, Leonid, Burkhardt, Harald, Alfredsson, Lars, Klareskog, Lars, Holmdahl, Rikard
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212587/ https://www.ncbi.nlm.nih.gov/pubmed/17897462 http://dx.doi.org/10.1186/ar2299

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