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Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L
BACKGROUND: Formation of haploid spermatozoa capable of fertilization requires proper programming of epigenetic information. Exactly how DNMT3L (DNA methyltransferase 3-Like), a postulated regulator of DNA methyltransferase activity, contributes to DNA methylation pattern acquisition during gametoge...
Autores principales: | La Salle, Sophie, Oakes, Christopher C, Neaga, Oana R, Bourc'his, Déborah, Bestor, Timothy H, Trasler, Jacquetta M |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212652/ https://www.ncbi.nlm.nih.gov/pubmed/17875220 http://dx.doi.org/10.1186/1471-213X-7-104 |
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